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Ferric derisomaltose and tranexamic acid, combined or alone, for reducing blood transfusion in patients with hip fracture (the HiFIT trial): a multicentre, 2 × 2 factorial, randomised, double-blind, controlled trial.
Lancet Haematol
September 2023
Département Anesthésie-Réanimation, Pôle Anesthésie Samu Urgences Réanimation, Centre Hospitalier Universitaire d'Angers, Angers, France.
Background: Anaemia and blood transfusion are associated with poor outcomes after hip fracture. We evaluated the efficacy of intravenous iron and tranexamic acid in reducing blood transfusions after hip fracture surgery.
Methods: In this double-blind, randomised, 2 × 2 factorial trial, we recruited adults hospitalised for hip fractures in 12 medical centres in France who had preoperative haemoglobin concentrations between 9·5 and 13·0 g/dL.
Quadratus Lumborum Block with Laparoscopic Assisted Catheter Placement Technique in Donor Nephrectomy: A Preliminary Report.
Transplant Proc
September 2022
Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesia, Istanbul, Turkey.
Quadratus lumborum block (QLB) is a new fascial plane block that may be helpful for laparoscopic surgeries. In this present study, we aim to evaluate the analgesic efficacy of QLB in laparoscopic living related donor nephrectomy (LLRDN) applied continuously via a catheter that was placed under laparoscopic vision by the surgeon. Following the approval of the Clinical Research Ethics Committee of Istanbul University, Istanbul Medical Faculty (2019/1552), 9 study (Group QLB) and 26 control (Group M) patients that underwent LLRDN were enrolled in this retrospective study.
View Article and Find Full Text PDFAssessment of potential differences between pre-filled and manually prepared syringe use during vascular access device management in a pediatric intensive care unit.
J Vasc Access
November 2022
Department of Pediatric Infectious Diseases, Dr. Behcet Uz Children's Disease and Surgery Training and Research Hospital, Izmir, Turkey.
Background: Central line-associated bloodstream infection is one of the four primary health-care-associated infections applicable to pediatric intensive care units defined by The Centers for Disease Control and Prevention. According to current guidelines, it is essential to flush vascular access devices before each infusion to assess catheter function and prevent catheter-related complications.
Objective: This prospective trial aimed to assess the potential differences between pre-filled and manually prepared saline syringe use during vascular access device management in a pediatric intensive care unit.
Continuous-Infusion Vancomycin in Neonates: Assessment of a Dosing Regimen and Therapeutic Proposal.
Front Pediatr
May 2019
Neonatal Intensive Care Unit, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
Vancomycin remains the reference antibiotic in neonates for care-related infections caused by ß-lactam-resistant Gram-positive bacteria. Achieving the optimal serum vancomycin level is challenging because of high inter-individual variability and the drug's narrow therapeutic window. Continuous infusion might offer pharmacokinetic and practical advantages, but we lack consensus on the dosing regimen.
View Article and Find Full Text PDFPharmacokinetics of liposomal curcumin (Lipocurc™) infusion: effect of co-medication in cancer patients and comparison with healthy individuals.
Cancer Chemother Pharmacol
February 2019
SignPath Pharma, Inc, 51 East 82 Street, #1A, New York, NY, 10028, USA.
Article Synopsis
- The study explored how co-medications affect plasma levels of curcumin and tetrahydrocurcumin in cancer patients, also comparing their pharmacokinetics to healthy individuals receiving Lipocurc™ (liposomal curcumin).
- Findings revealed that certain co-medications, particularly those targeting the renin-angiotensin system like Lisinopril, Ramipril, and Valsartan, significantly increased curcumin and THC plasma levels in patients, while infusion rate also influenced these levels.
- The research concluded that both the presence of co-medications and the health status of patients play a role in how curcumin properties are absorbed and eliminated in the body
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