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Relationship Between Pre- and Post-Orchidectomy Serum Dihydrotestosterone and Prostate Cancer Severity in a Cohort of Nigerian Patients.
West Afr J Med
September 2024
Urology Department, Dorset County Hospital, Dorchester, UK.
Introduction: Prostate cancer (PCa) is the commonest urologic cancer worldwide and the leading cause of male cancer deaths in Nigeria. In Nigeria, orchidectomy remains the primary androgen deprivation therapy. Dihydrotestosterone (DHT) is the active prostatic androgen, but its relationship with PCa severity has not been extensively studied in Africa.
View Article and Find Full Text PDFBifunctional poly(1,3-dioxolane)-graphitic CN composite interlayers enable stable and compatible anode interfaces in solid lithium batteries.
J Colloid Interface Sci
April 2025
College of Physics, Qingdao University, Qingdao 266071, China. Electronic address:
Polyacrylonitrile (PAN)-based composite solid electrolytes (CSEs) hold great promise in the practical deployment of solid lithium batteries (SLBs) owing to their high voltage stability but suffer from poor stability against Li-metal. Herein, a poly(1,3-dioxolane) (PDOL)-graphitic CN (g-CN, i.e.
View Article and Find Full Text PDFAcid triggering highly-efficient release of reactive oxygen species to block mitochondrial-mediated homeostasis maintenance for accelerating cell death.
Anal Chim Acta
February 2025
School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education, Hefei, 230601, PR China; School of Chemical and Environmental Engineering, Anhui Polytechnic University, 241000, Wuhu, PR China. Electronic address:
A pivotal pathway of photodynamic therapy (PDT) is to prompt mitochondrial damage by reactive oxygen species (ROS) generation, thus leading to cancer cell apoptosis. However, mitochondrial autophagy is induced during such a PDT process, which is a protective mechanism for cancer cell homeostasis, resulting in undermined therapeutic efficacy. Herein, we report a series of meticulously designed donor (D)-π-acceptor (A) photosensitizers (PSs), characterized by the strategic modulation of thiophene π-bridges, which exhibit unparalleled mitochondrial targeting proficiency.
View Article and Find Full Text PDFA chitosan-based sensing membrane for on-site and sensitive dual-channel portable detection and efficient adsorption of Pb in groundwater.
Anal Chim Acta
February 2025
State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Gansu, Lanzhou, 730000, China. Electronic address:
The presence of lead ion (Pb) in groundwater poses a serious risk to human health, even at low levels. Therefore, it is essential to develop a new strategy for both selective detection and effective removal of Pb in groundwater, which has been rarely reported. Here, we developed a multi-functional chitosan-based fluorescent sensing membrane (CM-L/CG) by using a casting method for the sensitive/selective detection and removal of Pb in groundwater.
View Article and Find Full Text PDFNanolabels for biosensors based on lateral flow immunoassays.
Anal Chim Acta
February 2025
Department of Physical and Analytical Chemistry & Institute of Biotechnology of Asturias, University of Oviedo, c/Julián Clavería 8, 33006, Oviedo, Spain. Electronic address:
The COVID-19 outbreak was an important turning point in the development of a new generation of biosensing technologies. The synergistic combination of an immunochromatographic test (lateral flow immunoassays, LFIA) and signal transducers provides enhanced sensitivity and the ability to quantify in the rapid tests. This is possible due to the variety of nanoparticles that can be used as reporter labels.
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