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Sodium tripolyphosphate is a non-toxic and economic alternative to glutaraldehyde for preparation of L-asparaginase CLEAs to reduce acrylamide in potato fries.
Food Chem
January 2025
Food Engineering and Technology Department, Institute of Chemical Technology, Matunga, Mumbai-400 019, India. Electronic address:
L-Asparaginase CLEAs were prepared utilizing sodium tripolyphosphate (TPP) as a crosslinker (TA-CLEA). Under optimized conditions (pH 3, 0.3% TPP concentration, and a crosslinking time of 1 h), an 85% activity recovery was achieved.
View Article and Find Full Text PDFl-Asparaginase Immobilized on Nanographene Oxide as an Efficient Nanobiocatalytic Tool for Asparagine Depletion in Leukemia Cells.
Bioconjug Chem
January 2025
Department of Biochemistry, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, ul. Lwowska 1, 87-100 Torun, Poland.
l-Asparaginase (l-ASNase) catalyzes the hydrolysis of l-asparagine, leading to its depletion and subsequent effects on the cellular proliferation and survival. In contrast to normal cells, malignant cells that lack asparagine synthase are extremely susceptible to asparagine deficiency. l-ASNase has been successfully employed in treating pediatric leukemias and non-Hodgkin lymphomas; however, its usage in adult patients and other types of cancer is limited due to significant side effects and drug resistance.
View Article and Find Full Text PDFA prognostic index for advanced-stage extranodal natural killer/T-cell lymphoma: A multicenter study.
Ann Hematol
January 2025
Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, No. 55, Section 4, South Renmin Road, Chengdu, 610042, China.
Advanced-stage extranodal natural killer/T-cell lymphoma (ENKTL) is a highly heterogeneous disease with very poor prognosis. All commonly utilized prognostic models incorporated both early-stage and advanced-stage patients in the modeling process. This study aim to design a prognostic model specifically for advanced-stage ENKTL, providing risk stratification in affected patients.
View Article and Find Full Text PDFAcute Myeloid Leukaemia and Acute Lymphoblastic Leukaemia Classification and Metabolic Characteristics for Informing and Advancing Treatment.
Cancers (Basel)
December 2024
Food, Microbiome and Health Research Programme, Quadram Institute Bioscience, Norwich NR4 7UQ, UK.
Acute myeloid leukaemia (AML) and acute lymphoblastic leukaemia (ALL) remain significant challenges in haematological oncology. This review examines the pathophysiology, classification, and risk stratification of these aggressive malignancies, emphasising their impact on treatment strategies and prognosis. We discuss current standard-of-care treatments, including chemotherapy regimens and targeted therapies, while addressing the associated adverse effects and hypersensitivity reactions.
View Article and Find Full Text PDFComparative studies on modeling and optimization of fermentation process conditions for fungal asparaginase production using artificial intelligence and machine learning techniques.
Prep Biochem Biotechnol
January 2025
Department of Biotechnology, Arunai Engineering College, Tiruvannamalai, India.
The L-asparaginase is commercial enzyme used as chemotherapeutic agent in cancer treatment and food processing agent in backed and fried food industries. In the present research work, the artificial intelligence and machine learning techniques were employed for modeling and optimization of fermentation process conditions for enhanced production of L-asparaginase by submerged fermentation of . The experimental L-asparaginase activity obtained using central composite experiment design was used for optimization.
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