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Early systemic insults following severe sepsis-associated encephalopathy of critically ill patients: association with mortality and awakening-an analysis of the OUTCOMEREA database.
J Intensive Care
January 2025
Medical and Infectious Diseases, ICU, Hospital Bichat-Claude Bernard, Université Paris Cité, AP-HP, Paris, France.
Background: Sepsis-associated encephalopathy (SAE) may be worsened by early systemic insults. We aimed to investigate the association of early systemic insults with outcomes of critically ill patients with severe SAE.
Methods: We performed a retrospective analysis using data from the French OUTCOMEREA prospective multicenter database.
Noniatrogenic hypoglycemia: A universal marker for poor outcomes.
JTCVS Open
December 2024
Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Objective: Previous retrospective studies have established a relationship between postoperative hypoglycemia and adverse outcomes after cardiac surgery, but none have accounted for the cause of hypoglycemia.
Methods: A retrospective review was performed of patients who underwent cardiac surgery at a single institution between 2016 and 2021. Patients were categorized as hypoglycemic if they had 1 or more postoperative blood glucose measurement less than 70 mg/dL and normoglycemic otherwise.
Diazoxide-Associated Hyperglycemia: A Critical Case Precipitating Hyperosmolar Hyperglycemic State in a Child.
J Med Toxicol
January 2025
Division of Pediatric Emergency Medicine, Johns Hopkins Children's Center, 1800 Orleans Street, Baltimore, MD, 21287, USA.
Introduction: Diazoxide is the first-line treatment for children with hyperinsulinemic hypoglycemia (HI). In these cases, diazoxide raises blood glucose levels by suppressing insulin release, preventing hypoglycemia, and potentially devastating end-organ sequelae. Hyperosmolar hyperglycemic state (HHS) is an exceedingly rare side effect of diazoxide.
View Article and Find Full Text PDFSuccessfully managed alcoholic ketoacidosis with sepsis leading to multiple organ dysfunction syndrome: a case report.
Folia Med (Plovdiv)
June 2024
ESIPGIMSR & ESIC Medical College, Kolkata, India.
Article Synopsis
- A 28-year-old male with a history of alcohol dependence and smoking experienced chest pain, shortness of breath, and confusion.
- He showed severe metabolic issues, including metabolic acidosis, low blood sugar, low platelet count, and acute kidney injury.
- Alcoholic ketoacidosis was suspected because of the presence of ketones in his urine, along with electrolyte imbalances and pneumonia observed in imaging tests.
Effect of Continuous Infusion vs Bolus Dose of Hydrocortisone in Septic Shock: A Prospective Randomized Study.
Indian J Crit Care Med
September 2024
Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
Article Synopsis
- This study explores how continuous infusion vs. bolus dosing of hydrocortisone affects blood glucose levels in adult patients with septic shock needing vasopressors.
- Forty patients were divided into two groups: one received continuous hydrocortisone (200 mg/day), while the other received intermittent bolus doses (50 mg every 6 hours).
- Results showed that both dosing methods had similar impacts on blood glucose, insulin needs, and shock reversal rates, suggesting no significant advantage of one method over the other.
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