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Treatment options for hypertrophic obstructive cardiomyopathy: a patient-centric review.
Expert Rev Cardiovasc Ther
November 2024
Inherited and Rare Cardiovascular Disease Unit, Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', AORN dei Colli, Monaldi Hospital, Naples, Italy.
Article Synopsis
- Hypertrophic cardiomyopathy (HCM) is a condition characterized by thickening of the heart's left ventricle walls, affecting 1 in 200-500 people, with 60% of cases being hereditary.
- The review discusses various treatments for HCM, including medications (like beta-blockers and calcium channel blockers) and surgical options, along with the importance of personalized patient care in improving outcomes.
- Future treatments, such as new drugs and gene therapies, are also highlighted, emphasizing the significance of tailoring management strategies to individual patient needs and preferences.
Promising therapies for adults with symptomatic obstructive hypertrophic cardiomyopathy: 2023 and beyond.
Expert Opin Pharmacother
May 2024
Hypertrophic Cardiomyopathy Center, Cleveland Clinic, Cleveland, OH, USA.
Introduction: Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart disease with an estimated prevalence in the general population of 0.2% to 0.6%.
View Article and Find Full Text PDFContemporary Therapies and Future Directions in the Management of Hypertrophic Cardiomyopathy.
Cardiol Ther
December 2022
Division of Cardiovascular Medicine, Department of Medicine, Perelman Center for Advanced Medicine, Perelman School of Medicine at the University of Pennsylvania, 11th Floor South Tower, Philadelphia, PA, 19104, USA.
Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by pathogenic variants in sarcomeric genes, leading to left ventricular hypertrophy and complex phenotypic heterogeneity. While HCM is the most common inherited cardiomyopathy, pharmacological treatment options have previously been limited and were predominantly directed towards symptom control owing to left ventricular outflow obstruction. These therapies, including beta blockers, calcium channel blockers, and disopyramide, have not been shown to affect the natural history of the disease, which is of particular concern for younger patients who have an increased lifetime risk of experiencing arrhythmias, heart failure, and sudden cardiac death.
View Article and Find Full Text PDFFrequent occurrence of postbreakfast syncope due to carotid sinus syndrome after surgery for hypopharyngeal cancer: A case report.
Medicine (Baltimore)
May 2021
Department of General Medicine, National Defense Medical College, Tokorozawa, Saitama.
Article Synopsis
- A 73-year-old man developed frequent, time-specific syncopal episodes (loss of consciousness) after undergoing surgery for recurrent hypopharyngeal cancer, which were linked to the impact of his tumor on his autonomic nervous system.
- *Diagnostic tests revealed complications from surgery, including an anastomotic stricture and carotid sinus syndrome, potentially triggered by swallowing and positional changes that affected blood flow.
- *Treatment with disopyramide successfully reduced these syncopal episodes, and heart rate variability analysis indicated a shift from parasympathetic to sympathetic dominance in the morning hours, suggesting a link between autonomic tone and syncope.*
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