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Seismocardiography as a tool for assessment of bi-ventricular pacing.
Physiol Meas
October 2022
Aalborg University, Department of Health Science and Technology, CardioTech, Denmark.
Conduction-induced heart failure in patients with left bundle branch block (LBBB) can benefit from cardiac resynchronization therapy (CRT). However, some patients are non-responders to the therapy with one contributing factor being poor optimization of the atrioventricular (AV) pacing delay. In this study, we have investigated the pacing-induced changes in the seismocardiogram (SCG).
View Article and Find Full Text PDFA role for membrane shape and information processing in cardiac physiology.
Pflugers Arch
January 2015
Innovative Medicines and Early Development, Cardiovascular and Metabolic Diseases iMed, AstraZeneca Research and Development Mölndal, Pepparedsleden 1, SE-431 83, Mölndal, Sweden,
While the heart is a dynamic organ and one of its major functions is to provide the organism with sufficient blood supply, the regulatory feedback systems, which allow adaptation to hemodynamic changes, remain not well understood. Our current description of mechanosensation focuses on stretch-sensitive ion channels, cytoskeletal components, structures such as the sarcomeric Z-disc, costameres, caveolae, or the concept of tensegrity, but these models appear incomplete as the remarkable plasticity of the myocardium in response to biomechanical stress and heart rate variations remains unexplained. Signaling activity at membranes depends on their geometric parameters such as surface area and curvature, which links shape to information processing.
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