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Psycho-Neuro-EndocrinE-Immunology Therapy of Cancer, Autoimmunity, Geriatric Disorders, Covid-19, and Hypertension.
Methods Mol Biol
November 2024
Pontificia Universitad Catolica, Buenos Aires, Argentina.
Despite the great number of experimental investigations in the area of psycho-neuro-endocrine-immunology showing that endocrine, nervous, and immune systems cannot be in vivo physiologically separated, the diagnosis and therapies of the pathologies of these three functional biological systems continue to be separately performed from a clinical practice point of view. The separation between experimental and clinical medicine became dramatic after the discovery of more than 10 human molecules provided by anti-inflammatory and antitumor activity, completely devoid of any toxicity, which may be subdivided into three fundamental classes, consisting of the pineal indole, beta-carboline, and methoxy-kynuramine hormones. Moreover, human systemic diseases, including cancer, autoimmunity, and cardiovascular pathologies, despite their different pathogenesis and symptomatology, are commonly characterized by a progressive decline in the endogenous production of pineal hormones, endocannabinoids, and Ang 1-7, with a consequent inflammatory status and diminished natural resistance against cancer.
View Article and Find Full Text PDFMelatonin and brain barriers: The protection conferred by melatonin to the blood-brain barrier and blood-cerebrospinal fluid barrier.
Front Neuroendocrinol
October 2024
CICS-UBI-Health Sciences Research Centre, Universidade da Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilhã, Portugal; Instituto Politécnico da Guarda, 6300-559 Guarda, Portugal. Electronic address:
Article Synopsis
- The blood-brain barrier and blood-cerebrospinal fluid barrier are crucial for protecting the brain from harmful substances and maintaining its functions.
- Disruption of these barriers is linked to various neurological diseases, highlighting their importance.
- Melatonin, a hormone produced by the pineal gland, may help protect these barriers due to its anti-inflammatory and antioxidant properties, making it important to study its role in barrier integrity.
Chicken Secondary Lymphoid Tissues-Structure and Relevance in Immunological Research.
Animals (Basel)
August 2024
Department of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland.
Recent discoveries have indicated the importance of developing modern strategies for vaccinations, more ethical research models, and effective alternatives to antibiotic treatment in farm animals. Chickens () play a crucial role in this context given the commercial and economic relevance of poultry production worldwide and the search for analogies between the immune systems of humans and birds. Specifically, chicken secondary lymphoid tissues share similar features to their human counterparts.
View Article and Find Full Text PDFComparison of the efficacy of royal jelly and melatonin combinations in experimentally induced wounds in geriatric and young mice.
Ulus Travma Acil Cerrahi Derg
June 2024
Faculty of Milas Veterinary Medicine, Mugla Sitki Kocman University, Muğla, Türkiye.
Background: Wound healing involves the repair of skin and other soft tissues after an injury. Royal jelly, a product of bees, possesses antioxidant, anti-inflammatory, antibacterial, and antiviral properties. Melatonin, a circadian indoleamine, is produced in the pineal gland and other organs.
View Article and Find Full Text PDFBinding and unbinding of potent melatonin receptor ligands: Mechanistic simulations and experimental evidence.
J Pineal Res
March 2024
Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy.
The labeled ligand commonly employed in competition binding studies for melatonin receptor ligands, 2-[I]iodomelatonin, showed slow dissociation with different half-lives at the two receptor subtypes. This may affect the operational measures of affinity constants, which at short incubation times could not be obtained in equilibrium conditions, and structure-activity relationships, as the K values of tested ligands could depend on either interaction at the binding site or the dissociation path. To address these issues, the kinetic and saturation binding parameters of 2-[I]iodomelatonin as well as the competition constants for a series of representative ligands were measured at a short (2 h) and a long (20 h) incubation time.
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