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Histopathological, Cytological and Radiological Correlations in Allergy and Public Health Concerns: A Comprehensive Review.
J Asthma Allergy
December 2024
Department of Public Health, School of Allied Medical Sciences, Kampala International University, Western Campus, Ishaka, Bushenyi, Uganda.
Allergies represent a significant and growing public health concern, affecting millions worldwide and burdening healthcare systems substantially. Accurate diagnosis and understanding of allergy is crucial for effective management and treatment. This review aims to explore the historical evolution, current advances, and prospects of histopathological and cytological techniques in allergy diagnosis, highlighting their crucial role in modern medicine.
View Article and Find Full Text PDFChromatin Topological Domains Associate With the Rapid Formation of Tandem Duplicates in Plants.
Adv Sci (Weinh)
December 2024
School of Advanced Agriculture Sciences and School of Life Sciences, Academy for Advanced Interdisciplinary Studies, State Key Laboratory of Protein and Plant Gene Research, Peking University, Beijing, 100871, China.
In eukaryotes, chromatin is compacted within nuclei under the principle of compartmentalization. On top of that, condensin II establishes eukaryotic chromosome territories, while cohesin organizes the vertebrate genome by extruding chromatin loops and forming topologically associating domains (TADs). Thus far, the formation and roles of these chromatin structures in plants remain poorly understood.
View Article and Find Full Text PDFPatient and Tumor Factors on Overall Survival in Spindle Cell Melanoma.
Cureus
November 2024
Oncology, Creighton University School of Medicine, Omaha, USA.
Introduction: Spindle cell melanoma (SCM) is a rare melanoma subtype characterized histologically by atypical, spindled, malignant melanocytes. SCM often presents in older patients and lacks typical cytologic markers, complicating diagnosis and frequently leading to advanced disease upon presentation. While some studies have documented SCM incidence, none have thoroughly examined the demographic, socioeconomic, and treatment factors influencing survival outcomes.
View Article and Find Full Text PDFEvaluating the feasibility of using whole blood gene expression profiles to identify novel targets in canine septic peritonitis.
Am J Vet Res
December 2024
Ethos Discovery, Sorrento Valley, CA.
Objective: To assess gene expression profiles in canine whole blood with and without septic peritonitis to assess workflow feasibility and identify potential blood biomarkers that could be further investigated in future studies.
Methods: This study enrolled 6 dogs with cytologically confirmed septic peritonitis of any cause and 6 healthy dogs. All dogs had a CBC and biochemistry performed.
An Integrated Dual-Layer Heterogeneous Polycaprolactone Scaffold Promotes Oral Mucosal Wound Healing through Inhibiting Bacterial Adhesion and Mediating HGF-1 Behavior.
Research (Wash D C)
October 2024
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China.
Article Synopsis
- The study focuses on a dual-layer polycaprolactone (PCL) scaffold designed to enhance soft tissue repair in oral mucosal defects.
- The scaffolds feature different fiber patterns (parallel, rhombic, square) and showed improved properties like surface wettability and tensile strength compared to disordered scaffolds.
- Notably, the square-patterned scaffold promoted cell differentiation and accelerated wound healing, suggesting strong potential for clinical applications in a bacteria-prone oral environment.
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