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Congenital and Perinatal Viral Infections: Consequences for the Mother and Fetus.
Viruses
October 2024
Feto Maternal Centre, Al Markhiya Doha, Doha P.O. Box 34181, Qatar.
Viruses are the most common congenital infections in humans and an important cause of foetal malformations, neonatal morbidity, and mortality. The effects of these infections, which are transmitted in utero (transplacentally), during childbirth or in the puerperium depend on the timing of the infections. These vary from miscarriages (usually with infections in very early pregnancy), congenital malformations (when the infections occur during organogenesis) and morbidity (with infections occurring late in pregnancy, during childbirth or after delivery).
View Article and Find Full Text PDFDoes Tobacco Smoking Affect Vaccine-Induced Immune Response? A Systematic Review and Meta-Analysis.
Vaccines (Basel)
November 2024
Department of Medical, Movement and Wellbeing Sciences, University of Naples "Parthenope", 80133 Naples, Italy.
. Causing approximately 8 million deaths each year, tobacco smoking represents a significant public health concern. Evidence shows that smoking significantly impairs antibody production and immune cell activity following vaccination.
View Article and Find Full Text PDFAdverse events following Measles-Mumps-Rubella and varicella immunization: A safety profile analysis and comparison of different vaccination schedules based on the Italian Pharmacovigilance Network in the Veneto Region.
Prev Med Rep
May 2024
University of Verona, Neurosciences, Biomedicine and Movement Sciences Department, Verona, Italy.
Article Synopsis
- The study compares the safety profiles of the MMRV (measles, mumps, rubella, varicella) and MMR-V (measles, mumps, rubella with a separate varicella vaccine) vaccines in Italy.
- A total of 9,510 adverse event reports from the Veneto region were analyzed, with no significant safety concerns found for either vaccine type.
- The findings indicated higher rates of serious events in males aged 0-2 years, although these differences did not affect the overall safety of the vaccines, warranting further research.
Transplacental transfer of anti-SARS-CoV-2 neutralizing antibodies in comparison to other pathogens total antibodies.
J Clin Virol
August 2023
Université Paris-Saclay, Inserm U1193, AP-HP, Hôpital Paul Brousse, Virology department, Villejuif 94800, France; Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), France. Electronic address:
Backgrounds: Due to immaturity of their immune system, passive maternal immunization is essential for newborns during their first months of life. Therefore, in the current context of intense circulation of SARS-CoV-2, identifying factors influencing the transfer ratio (TR) of neutralizing antibodies against SARS-CoV-2 (NAb) appears important.
Methods: Our study nested in the COVIPREG cohort (NCT04355234), included mothers who had a SARS-CoV-2 PCR positive during their pregnancy and their newborns.
A Live Attenuated COVID-19 Candidate Vaccine for Children: Protection against SARS-CoV-2 Challenge in Hamsters.
Vaccines (Basel)
January 2023
Serum Institute of India Pvt. Ltd., Pune 411028, Maharashtra, India.
Children are at risk of infection from severe acute respiratory syndrome coronavirus-2 virus (SARS-CoV-2) resulting in coronavirus disease (COVID-19) and its more severe forms. New-born infants are expected to receive short-term protection from passively transferred maternal antibodies from their mothers who are immunized with first-generation COVID-19 vaccines. Passively transferred antibodies are expected to wane within first 6 months of infant's life, leaving them vulnerable to COVID-19.
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