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Disrupted NAD(P) Metabolism and Xanthine Dehydrogenase in a Stress-Induced Rat Model of Depression: NMR Metabolomics Insights.
Metabolites
November 2024
School of Life and Health Science, Anhui Science and Technology University, Fengyang 233100, China.
: Clinical findings have shown a negative correlation between the severity of depressive symptoms and serum uric acid levels in men, yet the role of metabolic regulation in the pathophysiology of depression remains largely unknown. : In this study, we utilized an acute restraint-stress-induced male rat model of depression to investigate biochemical changes through NMR-based metabolomics combined with serum biochemical analysis. Additionally, we employed qPCR, immunoblotting, and enzyme activity assays to assess the expression and activity of xanthine oxidoreductase, the rate-limiting enzyme in uric acid production.
View Article and Find Full Text PDFSerum uric acid and nonalcoholic fatty liver disease.
Front Endocrinol (Lausanne)
December 2024
Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, China.
Nonalcoholic fatty liver disease (NAFLD) is characterized by over 5% hepatic fat accumulation without secondary causes. The prevalence of NAFLD has escalated in recent years due to shifts in dietary patterns and socioeconomic status, making it the most prevalent chronic liver disease and a significant public health concern globally. Serum uric acid (SUA) serves as the end product of purine metabolism in the body and is intricately linked to metabolic syndrome.
View Article and Find Full Text PDF[ (Blume) Miq] maintains uric acid homeostasis via regulating gut microbiota and restrains renal inflammation in hyperuricemic nephropathy.
Front Pharmacol
November 2024
State key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Introduction: The kidney damage caused by the deposition of uric acid in the kidneys is of urgent need for new treatment drugs due to its complex pathogenesis. (Blume) Miq. Also known as , which has a significant therapeutic effect on hyperuricemia nephropathy (HN), however, the specific mechanism of its action is still unknown.
View Article and Find Full Text PDFAnti-hyperuricemic effects of the seeds of Hovenia acerba in hyperuricemia mice.
J Ethnopharmacol
December 2024
State Key Laboratory of Functions and Applications of Medicinal Plants & School of Pharmaceutical Sciences, Guizhou Medical University, 6 Ankang Avenue, Guian New District, 561113, Guizhou, China; University Engineering Research Center for the Prevention and Treatment of Chronic Diseases By Authentic Medicinal Materials in Guizhou Province, 6 Ankang Avenue, Guian New District, 561113, Guizhou, China; Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, 6 Ankang Avenue, Guian New District, 561113, Guizhou, China. Electronic address:
Ethnopharmacological Relevance: The seeds of Hovenia acerba water extract (HAW) are used as an edible traditional Chinese medicine to treat diseases related to hyperuricemia (HUA).
Aim Of The Study: To evaluate HAW for its anti-HUA effect and to figure out their underlying mechanisms.
Materials And Methods: The anti-HUA effects were evaluated on a mouse model by testing HAW's effects on the levels of serum uric acid (SUA), the biochemical indicators of liver and kidney function, and the histology of liver and kidney.
Ergothioneine Ameliorates Liver Fibrosis by Inhibiting Glycerophospholipids Metabolism and TGF-β/Smads Signaling Pathway: Based on Metabonomics and Network Pharmacology.
J Appl Toxicol
November 2024
Department of Anatomy, School of Basic Medicine, Shenyang Medical College, Shenyang, China.
Article Synopsis
- * In a study, mice treated with EGT showed improved liver function and reduced symptoms of fibrosis, evidenced by lower levels of liver enzymes and key markers associated with fibrosis.
- * Metabolomic and network pharmacology analyses suggested that EGT works through specific metabolic pathways and targets, particularly inhibiting the TGF-β/Smads signaling pathway, which could pave the way for new therapeutic strategies against liver fibrosis.
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