Results of using discriminant analysis for forecasting ischemic and hemorrhagic strokes are presented. Use was made of clinical data obtained from groups consisting of 400 patients with a history of ischemic strokes, 50 patients with a history of hemorrhagic strokes and 100 healthy individuals. Each observation in these groups was analyzed from 120 parameters and features. As a result of mathematical processing of these data 15 risk factors found to be the most informative for forecasting ischemic strokes, and 16 factors for forecasting hemorrhagic strokes were selected. The reliability of the identification capacity of the prognostic system was evaluated from generalized Machalanobis distance. The correctness of forecasting ischemic strokes was confirmed in 83% and of hemorrhagic strokes in 94.7% of the cases.
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Stroke
March 2025
Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, the Netherlands (Y.M.R.).
Brain arteriovenous malformations (AVMs), cerebral cavernous malformations (CCMs), and intracranial aneurysms are major causes of hemorrhagic stroke, yet noninvasive therapies to prevent growth or rupture are lacking. Understanding the genetic basis of these malformations is critical for uncovering underlying mechanisms, developing targeted prevention strategies, and identifying novel therapeutic targets. This review highlights the causal genes and signaling pathways in AVMs, CCMs, and intracranial aneurysms, noting both their commonalities and differences.
View Article and Find Full Text PDFHeliyon
February 2025
One Health Research Group, Faculty of Health Science, Universidad de Las Americas, Quito, Ecuador.
Snake bites represent a critical public health issue, affecting approximately 2.7 million people globally each year. Around 20 % of snake species are venomous, and their venom contains a complex array of toxins that can cause multi-organ damage, particularly affecting the nervous system, leading to both ischemic and hemorrhagic cerebrovascular events.
View Article and Find Full Text PDFFront Neurol
February 2025
Department of Neuroscience, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Background: Half of the patients who undergo successful recanalization after endovascular treatment (EVT) experience poor clinical outcomes. Impaired microvascular reperfusion (IMR) may explain this lack of improvement, but its frequency and clinical significance remain unclear. The study aims to describe the frequency and associated factors of IMR.
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February 2025
Department of Neurology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
Background: This study aimed to develop a clinical-radiomics model using hyperattenuated imaging markers (HIM), characterized by hyperattenuation on head non-contrast computed tomography immediately after thrombectomy, to predict the risk of hemorrhagic transformation (HT) in patients undergoing endovascular mechanical thrombectomy (MT).
Methods: A total of 159 consecutive patients with HIM were screened immediately after MT for inclusion. The datasets were randomly divided into training and test cohorts at a ratio of 8:2.
Neurology
April 2025
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Background And Objectives: Diabetes significantly increases the risk of cardiovascular events, including stroke. Although the association with ischemic stroke is well established, the relationship with hemorrhagic stroke remains unclear. This study aimed to evaluate the risk of ischemic and hemorrhagic stroke in individuals with type 1 and type 2 diabetes compared with diabetes-free controls from the general population.
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