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Pyrazinamide (PZA) is a critical component of tuberculosis first-line therapy due to its ability to kill both growing and non-replicating drug-tolerant populations of within the host. Recent evidence indicates that PZA acts through disruption of coenzyme A synthesis under conditions that promote cellular stress. In contrast to its bactericidal action , PZA shows weak bacteriostatic activity against in axenic culture.
View Article and Find Full Text PDFCompelling concerns about antimicrobial resistance and the emergence of multidrug-resistant pathogens call for novel strategies to address these challenges. Nanoparticles show promising antimicrobial activities; however, their actions are hindered primarily by the bacterial hydrophilic-hydrophobic barrier. To overcome this, we developed a method of electrochemically anchoring sodium dodecyl sulfate (SDS) coatings onto silver nanoparticles (AgNPs), resulting in improved antimicrobial potency.
View Article and Find Full Text PDFSynergistic antimicrobial effects of thiamine dilauryl sulphate combined with the heartwood extract of Pterocarpus marsupium and antifungal mechanism in their combination.
Lett Appl Microbiol
January 2025
Graduate School of Science, Osaka Metropolitan University, Osaka 558-8585, Japan.
Thiamine dilauryl sulphate (TDS) exerts a bacteriostatic effect against Gram-positive bacteria and is used as a food additive. The heartwood extract of the Indian kino tree (Pterocarpus marsupium), a medicinal tree native to India, shows weak antimicrobial effects against bacteria and superficial dermatophyte-infective fungi. Herein, we report that the combination of TDS and P.
View Article and Find Full Text PDFAntibacterial and antifungal activities of Moroccan wild edible plants selected based on ethnobotanical evidence.
Rocz Panstw Zakl Hig
December 2024
Laboratory of Anthropogenetic, Biotechnologies and Health, Department of Biology, Faculty of Sciences, Chouaib Doukkali University, El Jadida, Morocco.
Background: Despite the extensive literature focusing on identifying novel antimicrobials of plant origin, little work has been undertaken to examine the antimicrobial activity of wild edible plants.
Objective: The current research aimed to determine the in vitro antimicrobial activity of methanolic extract of some common wild edible plants.
Material And Methods: Disc diffusion and broth micro dilution methods were used to evaluate the antimicrobial activity of extracts of , , , , , , and against known human microorganisms' pathogens.
Development of Naphthalene-Derivative Bis-QACs as Potent Antimicrobials: Unraveling Structure-Activity Relationship and Microbiological Properties.
Molecules
November 2024
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.
While the pandemic is behind us, the world community faces a global threat of bacterial resistance outbreak. One of the key ways to combat the spread of multi-resistant bacteria is infection prevention and control tactics using modern antiseptic and disinfectant compositions. Herein, we continue the path to unravel the structure-activity relationship (SAR) of potent pyridine-derived biocide class bis-quaternary ammonium compounds (QACs).
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