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Atomoxetine-Induced Pheochromocytoma and Paraganglioma Crisis Managed With Veno-Arterial Extracorporeal Membrane Oxygenation.
Cureus
November 2024
Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Isehara, JPN.
Pheochromocytoma and paragangliomas (PPGLs) crises can be triggered by various factors, including norepinephrine reuptake inhibitors used to treat attention deficit hyperactivity disorder (ADHD), which worsen symptoms in patients with PPGLs. Therefore, attention should be paid to the potential for serious adverse reactions in patients with PPGLs taking ADHD medications. A 21-year-old man presented to the emergency department with acute onset of severe respiratory and circulatory failure after initiating atomoxetine treatment.
View Article and Find Full Text PDFFemoral Artery Infusion of αMSH Increases Muscle Thermogenesis and Promotes Glucose Uptake in Ovariectomized Ewes.
Endocrinology
November 2024
Department of Physiology, Monash University, Clayton, VIC 3800, Australia.
Article Synopsis
- The melanocortin system plays a crucial role in controlling energy balance and weight regulation, with recent findings indicating its effects on peripheral tissues like skeletal muscle, independent of the brain or SNS.
- Infusing α-melanocyte-stimulating hormone (αMSH) directly into the femoral artery significantly increased heat production in skeletal muscle, while not affecting food intake, demonstrating its local action in energy expenditure.
- The study also revealed that αMSH infusion enhanced mitochondrial function, increased glucose uptake in skeletal muscle, and showed that blocking SNS with certain drugs did not impact αMSH's effects, highlighting its unique role in energy regulation.
Effectiveness of phentolamine mesylate, vibration and photobiomodulation in reducing pain and the reversal of local anesthesia: A systematic review.
Adv Clin Exp Med
November 2024
Department of Dental Surgery, Wroclaw Medical University, Poland.
Background: Dental anesthesia administration often triggers unpleasant sensations, particularly needle injection-related pain, which can evoke fear among patients, especially in the pediatric population. Vibration and low-level laser therapy (LLLT) have been extensively studied as potential methods for alleviating pain. Additionally, phentolamine mesylate (PM) has shown promise in reducing the duration of anesthesia.
View Article and Find Full Text PDFThe basolateral amygdala (BLA) contains adrenergic receptors, which are known to be involved in stress, anxiety, and memory. The objective of this study was to explore whether inhibition of α-adrenergic receptors (by phentolamine, an α-adrenergic receptor antagonist) in the BLA can reduce foot-shock stress-induced anxiety-like behavior, memory deficits, and long-term potentiation (LTP) deficits within the CA1 region of the rat hippocampus. Forty male Wistar rats were assigned to the intact, control, stress (Str), Phent (phentolamine), and Phent + Str groups.
View Article and Find Full Text PDFA human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration.
Cell Stem Cell
December 2024
State Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, China. Electronic address:
Article Synopsis
- This study focuses on improving cartilage regeneration using stem cells by addressing issues like off-target differentiation and hypertrophic tendencies.
- Researchers created a system to monitor chondrogenesis and hypertrophy in real-time using stem cells with specific genetic markers and tested over 2,000 FDA-approved drugs.
- They discovered that the drug phentolamine promoted cartilage growth and avoided degeneration, suggesting the α2-AR/SLPI pathway as a potential target for effective cartilage regeneration.
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