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Autoreactive antibodies control blood glucose by regulating insulin homeostasis.
Proc Natl Acad Sci U S A
February 2022
Institute of Immunology, Ulm University Medical Center, 89081 Ulm, Germany;
Homeostasis of metabolism by hormone production is crucial for maintaining physiological integrity, as disbalance can cause severe metabolic disorders such as diabetes mellitus. Here, we show that antibody-deficient mice and immunodeficiency patients have subphysiological blood glucose concentrations. Restoring blood glucose physiology required total IgG injections and insulin-specific IgG antibodies detected in total IgG preparations and in the serum of healthy individuals.
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