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ALC-0315 Lipid-Based mRNA LNP Induces Stronger Cellular Immune Responses Postvaccination.
Mol Pharm
January 2025
Ningbo No.2 Hospital, Ningbo, Zhejiang 315010, P. R. China.
At the end of 2019, SARS-CoV-2 emerged and rapidly spread, having a profound negative impact on human health and socioeconomic conditions. In response to this unprecedented global health crisis, significant advancements were made in the mRNA vaccine technology. In this study, we have compared the difference between two SARS-CoV-2 receptor-binding domain (RBD) mRNA-Lipid nanoparticle (LNP) vaccines prepared from two different ionizable cationic lipids: ALC-0315 and MC3.
View Article and Find Full Text PDFLong-term cultivation of retinal pigment epithelium cells on nanofiber scaffolds.
Graefes Arch Clin Exp Ophthalmol
January 2025
Department of Ophthalmology, University Hospital Munster, Munster, Germany.
Purpose: The retinal pigment epithelium (RPE) plays an important role in the pathogenesis of age-related macular degeneration (AMD) and other retinal degenerative diseases. The introduction of healthy RPE cell cultures into the subretinal space offers a potential treatment strategy. The aim of this study was the long-term culture and characterisation of RPE cells on nanofiber scaffolds.
View Article and Find Full Text PDFElectrospun nanofibers as controlled release systems for the combined pheromones of Grapholita molesta and Cydia pomonella.
Pest Manag Sci
January 2025
College of Plant Protection, Shanxi Agricultural University, Taigu, China.
Background: As sex pheromones are environmentally friendly and specific, they are often used to monitor and control oriental fruit moths (OFMs). Currently, non-biodegradable polymers are commonly employed as carriers to prepare controlled sex pheromone release systems for plant protection. Electrospinning is a relatively simple technique for preparing biodegradable nanofibers that allows for the controlled release of sex pheromones.
View Article and Find Full Text PDFDouble-vestibular incision subperiosteal tunnel access (double-VISTA) with connective tissue graft for treating multiple gingival recessions: 2-year follow-up.
Clin Adv Periodontics
January 2025
Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, California, USA.
Background: Gingival recession has a multifactorial etiology, involving various predisposing and precipitating factors. Non-carious cervical lesions (NCCLs) are often associated with gingival recession and pose challenges due to their complex pathodynamics. There is limited evidence regarding tunnel-based procedures combined with connective tissue grafts (CTGs) for treating recession-associated NCCLs.
View Article and Find Full Text PDFModulation of RuO Nanocrystals with Facile Annealing Method for Enhancing the Electrocatalytic Activity on Overall Water Splitting in Acid Solution.
Adv Sci (Weinh)
January 2025
Key (Guangdong-Hong Kong Joint) Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, College of Chemical and Chemical Engineering, Shantou University, Shantou, 515041, P. R. China.
RuO-based materials are considered an important kind of electrocatalysts on oxygen evolution reaction and water electrolysis, but the reported discrepancies of activities exist among RuO electrocatalysts prepared via different processes. Herein, a highly efficient RuO catalysts via a facile hydrolysis-annealing approach is reported for water electrolysis. The RuO catalyst dealt with at 200 °C (RuO-200) performs the highest activities on both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in acid with overpotentials of 200 mV for OER and 66 mV for HER to reach a current density of 100 mA cm as well as stable operation for100 h.
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