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The transport of metabolites across the inner mitochondrial membrane (IMM) is crucial for maintaining energy balance and efficient distribution of metabolic intermediates between cellular compartments. Under abiotic stress, mitochondrial function becomes particularly critical, activating complex signaling pathways essential for plant stress responses. These pathways modulate stress-responsive gene expression, influencing key physiological processes such as cell respiration and senescence, helping plants adapt to stress.

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The importance of continuous and reliable pulse wave monitoring is constantly being increased in health signal monitoring and disease diagnoses. Flexible pressure sensors with high sensitivity, low hysteresis and fast response time are an effective means for monitoring pulses. Herein, a special wave-shaped layered porous structure of carbonized wood cellulose sponge (CWCS) was constructed based on natural wood (NW).

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Circadian Rhythm, Hypoxia, and Cellular Senescence: From Molecular Mechanisms to Targeted Strategies.

Eur J Pharmacol

January 2025

College of Life Science, Yangtze University, Jingzhou 434025, China. Electronic address:

Cellular senescence precipitates a decline in physiological activities and metabolic functions, often accompanied by heightened inflammatory responses, diminished immune function, and impaired tissue and organ performance. Despite extensive research, the mechanisms underpinning cellular senescence remain incompletely elucidated. Emerging evidence implicates circadian rhythm and hypoxia as pivotal factors in cellular senescence.

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Frailty and social contact with dementia risk: A prospective cohort study.

J Affect Disord

January 2025

Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China; Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing, China. Electronic address:

Background: Frailty and social contact are significant factors influencing dementia risk. While previous studies have separately examined these factors, their combined impact on dementia remains underexplored.

Methods: This study included 338,567 UK biobank participants from 2006 to 2010, with follow-up until December 2022.

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