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Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines.
Front Mol Biosci
January 2025
Faculty of Biology and Biotechnologies, National Research University Higher School of Economics, Moscow, Russia.
Introduction: Colorectal cancer (CRC) is characterized by an extremely high mortality rate, mainly caused by the high metastatic potential of this type of cancer. To date, chemotherapy remains the backbone of the treatment of metastatic colorectal cancer. Three main chemotherapeutic drugs used for the treatment of metastatic colorectal cancer are 5-fluorouracil, oxaliplatin and irinotecan which is metabolized to an active compound SN-38.
View Article and Find Full Text PDFSafety Evaluation of the Novel Cocktail of Monoclonal Antibodies for Postexposure Prophylaxis in Category III Animal Exposures.
J Glob Infect Dis
October 2024
Zydus Lifesciences Ltd., Ahmedabad, Gujarat, India.
Introduction: Rabies monoclonal antibody (mAb) is a life-saving immune-biological for postexposure prophylaxis (PEP) in all Category III animal exposures. A novel cocktail of mAbs derived using recombinant DNA technology is presently available for usage. The WHO recommends monitoring the clinical use and outcomes of mAb products.
View Article and Find Full Text PDFGemcitabine and cisplatin induction chemotherapy followed by concurrent chemoradiotherapy for stage III-IVA nasopharyngeal carcinoma: A real-world study.
Sci Prog
January 2025
Department of Head and Neck Cancer Radiotherapy, NgheAn Oncology Hospital, Vinh, Vietnam.
Introduction: This study aims to evaluate the efficacy of combining induction chemotherapy with concurrent chemoradiotherapy for patients with stage III-IVA nasopharyngeal carcinoma (NPC), particularly focusing on cases associated with Epstein-Barr virus infection. The primary focus is on treatment response and disease control.
Methods: This retrospective cohort study analyzed data from 81 patients with stage III-IVA NPC (excluding T3N0M0) treated with gemcitabine and cisplatin as induction chemotherapy, followed by concurrent chemoradiotherapy at the Vietnam National Cancer Hospital.
Cardiovascular risk assessment: Missing albuminuria contributing to gender inequality.
Nefrologia (Engl Ed)
January 2025
Division of Nephrology IIS-Fundacion Jimenez Diaz, Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain; RICORS2040, Carlos III Institute of Health, Madrid, Spain.
Introduction: Chronic kidney disease (CKD) is associated with high cardiovascular disease (CVD) risk, and requires specific interventions to decreases CVD risk. The guidelines indicate that systematic global CVD risk assessment is recommended in individuals with any major vascular risk factor. The European Society Cardiology (ESC) guidelines, he European Renal Association (ERA) Council and the Spanish Society of Nephrology (S.
View Article and Find Full Text PDFImpact of probiotic treatment on clinical symptom reduction in schizophrenia: A systematic review and meta-analysis.
J Psychiatr Res
January 2025
Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain; CIBERSAM-ISCIII (Biomedical Research Networking Centre for Mental Health/Carlos III Health Institute), Spain; Department of Legal Medicine, Psychiatry, and Pathology. Complutense University of Madrid, Madrid, Spain. Electronic address:
Introduction: Recent research has identified gut microbiota dysbiosis as a potential contributing factor in schizophrenia, leading to growing interest in exploring probiotics as a complementary approach to traditional antipsychotic treatments. This study aims to systematically evaluate the current evidence on the efficacy of probiotics in improving clinical symptoms of schizophrenia, offering a novel perspective into their potential role as an adjunctive strategy.
Methods: A systematic search was conducted to review randomized clinical trials, adhering to the PRISMA guidelines.
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