The protective effect of remantadin during an influenza outbreak in December 1977 caused by A (H1N1) virus was studied. A prophylactic administration of remantadin decreased influenza and ARD incidence by 1.5-fold. A more significant decrease of the incidence (2.5-fold) was observed among the subjects given a combination of remantadin and influenza vaccine (H3N2) a few days before the outbreak, which was apparently due to the interferon-inducing capacity of the vaccine.
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