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Nanosized core-shell bio-hybrid microgels and their internal structure.
Nanoscale
January 2025
Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, 52074 Aachen, Germany.
Microgels are versatile materials with applications across biomedicine, materials science, and beyond. Their controllable size and composition enables tailoring specific properties, yet characterizing their internal structures on the nanoscale remains challenging. Super-resolution fluorescence microscopy (SRFM) effectively analyzes sub-μm structures, including microgels, offering a tool for investigating more complex systems such as core-shell microgels.
View Article and Find Full Text PDFClearance of Intracellular Pathogens with Hyaluronic Acid Nanomicelles Responsive to HS and pH.
Molecules
December 2024
Engineering Laboratory of Chemical Resources Utilization in South Xinjiang, Tarim University, Alar 843300, China.
Hyaluronic acid (HA) is an acidic mucopolysaccharide of animal origin composed of repeating disaccharide units of N-acetylglucosamine and glucuronic acid. Due to its excellent biocompatibility, biodegradability, and selective affinity for CD44 receptors on cell surfaces, HA is widely employed as a drug carrier. In our study, we aimed to target subcellular bacteria by grafting cystamine onto HA scaffolds through an amide reaction, producing a linker responsive to HS and pH changes.
View Article and Find Full Text PDFSelectively Detachable Hydrogel Adhesion Enabled by Stimulus-Specific Cleavable Cross-Linkers.
ACS Appl Mater Interfaces
December 2024
Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
The development of detachable hydrogel adhesion presents an advancement in the fields of soft electronics and bioengineering as it offers additional functionalities to these applications. However, conventional methods typically rely on a single detachment trigger, so it is unclear whether unintentional detachment might occur in the specific environments of other detachment systems. This makes it difficult to directly introduce two independent detachment triggers directly.
View Article and Find Full Text PDFβ-cyclodextrin-modified carboxymethyl chitosan/hyaluronic acid-based crosslinked composite nanogels as a dual responsive carrier for targeting anti-tumor therapy.
Int J Pharm
December 2024
Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China; Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing 400016, China. Electronic address:
Advanced nanosized drug delivery systems can significantly improve efficacy and safety of first-line chemotherapeutics by enhancing tumor targeting. Herein, one-pot covalent crosslinking approach was developed to generate biodegradable tumor-targeted composite Nanogels from carboxymethyl chitosan, hyaluronic acid, cystamine and 6-ethylene-diamine-6-deoxy-β-cyclodextrin loaded with doxorubicin (DOX) for controlled intracellular DOX release. The optimized synthetic procedures generated Nanogels of about 190 nm in size and 28.
View Article and Find Full Text PDFLapatinib-loaded reductive-responsive hyaluronic acid-cholesterol nanoparticles for inhibiting metastasis of uveal melanoma.
Int J Biol Macromol
December 2024
National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China; University of Chinese Academy of Sciences Wenzhou Institute, Wenzhou 325001, China. Electronic address:
Uveal melanoma (UM) is the most common intraocular primary malignancy in adults with highly metastatic characteristics. Currently, there are no effective therapies to prevent metastasis formation in UM, resulting in a poor prognosis. Herein, we report a novel lapatinib-loaded reductive-responsive nanoparticle platform prepared via the self-assembly of amphiphilic hyaluronic acid-cystamine-cholesteryl hemisuccinate conjugate to suppress the distant metastasis of UM.
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