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Whole blood exchange ameliorates acute hemolytic anemia by reducing inflammation and oxidative stress in rats.
FASEB J
January 2025
Department of Blood Transfusion, Xiangya Hospital, Central South University, Changsha, China.
Hemolytic anemia (HA) is characterized by massive destruction of red blood cells (RBCs) and insufficient oxygen supply, which can lead to shock, organ failure, even death. Recent studies have preliminarily demonstrated the therapeutic effectiveness of whole blood exchange (WBE) in the management of acute hemolytic anemia and exhibited potential for reducing the duration of corticosteroid treatment, while the underlying mechanism of WBE therapy was not investigated in preclinical study. Hence, we investigate the therapeutic mechanisms of WBE in HA through established continued WBE therapy in rats creatively.
View Article and Find Full Text PDFEvaluation of the Effect of Virgin Rice Bran Oil (VRBO) on DoxorubicinInduced Cardiotoxicity in Wistar Rats.
Curr Cardiol Rev
January 2025
Department of Nutrition, Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France.
Objective: The usage of doxorubicin (DOX), an antineoplastic drug that is frequently used for the cure of cancer, is restricted to maximal doses due to its cardiac toxicity. Reactive oxygen species produced by DOX result in lipid peroxidation and organ failure, ultimately resulting in cardiomyopathy. Due to its high polyphenol content, virgin rice bran oil (VRBO) is a diet nutritional supplement with a strong antioxidant.
View Article and Find Full Text PDFBiological characterization of breast cancer spheroid formed by fast fabrication method.
In Vitro Model
February 2024
Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-Cho, Koganei, Tokyo 184-8588 Japan.
Unlabelled: Engineered three-dimensional (3D) tissue culture platforms are useful for reproducing and elucidating complex in vivo biological phenomena. Spheroids, 3D aggregates of living cells, are produced based on physicochemical or microfabrication technologies and are commonly used even in cancer pathology research. However, conventional methods have difficulties in constructing 3D structures depending on the cell types, and require specialized techniques/lab know-how to reproducibly control the spheroid size and shape.
View Article and Find Full Text PDFEffect of anemoside B4 on ameliorating cerebral ischemic/reperfusion injury.
Iran J Basic Med Sci
January 2025
Department of Basic Medicine, Chongqing Three Gorges Medical College, Chongqing 404100, China.
Objectives: Anemoside B4 (AB4) is a multifunctional compound with anti-inflammatory, anti-apoptotic, antioxidant, antiviral, and autophagy-enhancing effects. However, the role of AB4 in cerebral ischemia/reperfusion injury (CIRI) remains obscure. This experiment aims to investigate the pharmacological effects of AB4 in CIRI.
View Article and Find Full Text PDFOxygen Evolution Reaction of Amorphous/Crystalline Composites of NiFe(OH)/NiFeO.
ACS Nano
January 2025
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China.
Orbital structures are strongly correlated with catalytic performance, whereas their regulation strategy is still in pursuit. Herein, the Fe 3 and O 2 orbital hybridization was optimized by controlling the content of amorphous NiFe(OH) (a-NiFe(OH)), which was grown in situ on crystalline NiFeO (c-NiFeO) using an ultrasonic reduction method. The results of electron energy loss spectroscopy (EELS) and X-ray absorption spectra (XAS) revealed that the Fe-O orbital hybridization in a-NiFe(OH) is effectively strengthened by jointing with the adjacent oxygen (O) in c-NiFeO, which is further confirmed by the higher antibonding orbital energies based on density functional theory (DFT) calculations.
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