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Pre-assembled nanospheres in mucoadhesive microneedle patch for sustained release of triamcinolone in the treatment of oral submucous fibrosis.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
August 2024
Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University; Hunan Engineering Research Center for Oral Digital Intelligence and Personalized Medicine; Hunan 3D Printing Engineering Research Center of Oral Care; WANG Songling Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha 410078.
Objectives: Drug-loaded mucoadhesive silk fibroin (SF) microneedle patch can overcome the limitations of low bioavailability and significant pain associated with traditional treatment methods, such as topical application or injection of triamcinolone for oral submucous fibrosis (OSF). However, these systems release the drug too quickly, failing to meet the clinical requirements. This study aims to construct a mucoadhesive SF microneedle patch pre-assembled with silk fibroin nanospheres (SFN) and explore its ability to sustain the release of triamcinolone in the treatment of OSF.
View Article and Find Full Text PDFDermal drug delivery bilosomes: a synergistic integration for better therapeutic outcomes.
J Microencapsul
December 2024
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, Mumbai, India.
The dermal route is commonly used to deliver the drugs at the targeted site and achieve maximum therapeutic efficacy. The stratum corneum, the uppermost layer of the skin, presents a significant diffusional barrier for most drugs. Various nanoformulations face challenges such as limited drug absorption and inadequate retention at the targeted site, frequently hindering therapeutic efficacy.
View Article and Find Full Text PDFReduced diffusional limitations in carnation stems facilitate higher photosynthetic rates and reduced photorespiratory losses compared with leaves.
Physiol Plant
October 2024
Botany, School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland.
Article Synopsis
- Green stem photosynthesis is generally inefficient but can help desert plants, while little is known about this trait in non-desert plants like Dianthus caryophyllus, which has green stems similar in structure to its leaves.
- A study using gas exchange and chlorophyll fluorescence found that both leaves and stems of Dianthus caryophyllus can perform photosynthesis quite well, with stems having a higher capacity for CO2 assimilation despite leaves reacting faster to changes in light.
- The research indicates that the differences in photosynthetic performance between leaves and stems relate to adaptations for light and water conservation, with leaves protecting against excess light while stems optimize CO2 uptake.
The Particle Drifting Effect: A Combined Function of Colloidal and Drug Properties.
Mol Pharm
November 2024
Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, Connecticut 06269, United States.
The particle drifting effect, where nanosized colloidal drug particles overcome the diffusional resistance of the aqueous boundary layer adjacent to the intestinal wall and increase drug absorption rates, is drawing increasing attention in pharmaceutical research. However, mechanistic understanding and accurate prediction of the particle drifting effect remain lacking. In this study, we systematically evaluated the extent of the particle drifting effect affected by drug and colloidal properties, including the size, number, and type of the moving species using biphasic diffusion experiments combined with computational fluid dynamics simulations and mass transport analyses.
View Article and Find Full Text PDFGradient-induced instability in tumour spheroids unveils the impact of microenvironmental nutrient changes.
Sci Rep
September 2024
Department of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II, P. Le V. Tecchio 80, 80125, Naples, Italy.
Tumours often display invasive behaviours that induce fingering, branching and fragmentation processes. The phenomenon, known as diffusional instability, is driven by differential cell proliferation, migration, and death due to the presence of metabolite and catabolite concentration gradients. An understanding of the intricate dynamics of this spatially heterogeneous process plays a key role in the investigation of tumour growth and invasion.
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