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Biphasic effect of limonene on contraction of isolated rat aorta.
Chem Biol Interact
January 2025
Department of Biological Chemistry, Regional University of Cariri, 63105-000, Crato, CE, Brazil.
Article Synopsis
- Limonene, a compound in essential oils, demonstrates various health benefits like antifungal and antioxidant properties, but its effects can vary based on concentration, showing a biphasic response.
- The study investigates limonene's impact on rat aorta contractions, revealing it can enhance or inhibit contractions depending on the dose, particularly with phenylephrine.
- Understanding these dose-dependent effects is crucial for determining safe and effective therapeutic uses of limonene in clinical settings.
Correlation between antihypertensive drugs and cerebral hemodynamic parameters: insights from observational findings using transcranial Doppler.
Clin Physiol Funct Imaging
January 2025
Department of Neurology, Hospital das Clínicas, University of São Paulo Medical School, Brazil.
Background: Antihypertensives (AHD) can influence cerebral autoregulation (CA) and attenuate hypertrophic concentric remodelling of arterioles. The aim of this study was to examine the associations between AHD, CA and structural and functional properties of cerebral arteries.
Methods: In this observational, cross-sectional study 115 volunteers were divided in group 1 (non-hypertensive) [n = 30]; group 2 (hypertensive with systolic blood pressure [SBP] < 140 and diastolic blood pressure [DBP] < 90 mmHg) [n = 54]; group 3 (hypertensive with SBP ≥ 140 or DBP ≥ 90 mmHg) [n = 31] and simultaneous measurements of systemic blood pressure (BP) and middle cerebral artery blood flow velocity (CBFV) were obtained from digital plethysmography and transcranial Doppler.
Coronary microvascular dysfunction and autoregulatory capacity interfere with resting Dicrotic notch morphology.
Microvasc Res
January 2025
Department of Cardiology, Acibadem International Hospital, Istanbul, Turkey. Electronic address:
Coronary microvascular vasodilator capacity is substantially associated with coronary pressure waveform and dicrotic notch morphology, with or without concomitant epicardial disease. A prominent dicrotic notch is associated with preserved microvascular vasodilatory capacity and adequate resting microvascular tonus without relative hyperaemic state, cumulatively indicating a better microcirculatory health.
View Article and Find Full Text PDFBackground: In the present study, two structurally similar alkaloids from trees of Cinchona genus, chloroquine and cinchonine, were examined for their vasorelaxant effects in a model of phenylephrine-induced smooth muscle contractions.
Methods: Potential mechanisms of action associated with endothelial vasorelaxant compounds, voltage-gated Ca2+ channels (LTCCs), and inositol triphosphate receptors were examined in isolated rat aortic rings. Also, an in silico approach was used to predict the activity of the two test compounds.
Sulodexide Inhibits Arterial Contraction via the Endothelium-Dependent Nitric Oxide Pathway.
J Clin Med
April 2024
Department of Anesthesiology and Reanimation, Gulhane Training and Research Hospital, University of Health Sciences, Ankara 06010, Turkey.
: Sulodexide (SDX) is a drug known for restoring the glycocalyx, thereby offering endothelial protection and regulating permeability. Additionally, it has antithrombotic and anti-inflammatory properties and has shown arterial vasodilatory effects. Endothelial cells play a crucial role in maintaining homeostasis, with their dysfunction being a key contributor to loss in vasodilatory response, especially in arterial pathologies.
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