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Design of a novel aptamer/molecularly imprinted polymer hybrid modified Ag-Au@Insulin nanoclusters/Au-gate-based MoS nanosheet field-effect transistor for attomolar detection of BRCA1 gene.
Talanta
May 2023
Department of Physics, Razi University, 67149-67346, Kermanshah, Iran.
Early detection of breast cancer, the first main cause of death in women, with robust assay platforms using appropriate biomarkers is of great importance for diagnosis and follow-up of the disease progression. This paper introduces an extra selective and sensitive label-free aptasensor for the screening of BRCA1 gene biomarker by taking advantage of a gate modified with aptamer and molecularly imprinted polymer hybrid (MIP) as a new synthetic receptor film coupled with an electrolyte-gated molybdenum disulfide (MoS) field-effect transistor (FET). The Au gate surface of FET was modified with insulin stabilized bimetallic Ag-Au@nanoclusters (Ag-Au@InsNCs), after which, the immobilization of the hybridized aptamer and o-phenylenediamine was electropolymerized to form an aptamer-MIP hybrid receptor.
View Article and Find Full Text PDFHematuria and Proteinuria in a Patient With Recurrent Pulmonary Illnesses: A Quiz.
Am J Kidney Dis
June 2022
Department of Renal Medicine, University College London, Royal Free Hospital, London, United Kingdom.
Accurate long-term prediction of death for patients with cirrhosis.
Hepatology
September 2022
Renal-Electrolye and Hypertension Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Background And Aims: Cirrhosis is a major cause of death and is associated with extensive health care use. Patients with cirrhosis have complex treatment choices due to risks of morbidity and mortality. To optimally counsel and treat patients with cirrhosis requires tools to predict their longer-term liver-related survival.
View Article and Find Full Text PDFDiscovery of Novel Proteomic Biomarkers for the Prediction of Kidney Recovery from Dialysis-Dependent AKI Patients.
Kidney360
November 2021
Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas.
Article Synopsis
- - The study investigates how specific serum proteins can predict kidney recovery in patients with acute kidney injury requiring dialysis (AKI-D), showing that changes in protein levels are linked to recovery outcomes.
- - Serum samples from 72 patients revealed 119 proteins with altered levels; 53 were higher and 66 were lower in patients who recovered enough to stop dialysis compared to those who remained on it.
- - Key proteins like CXCL11 and Wnt-7a were identified as significantly associated with better recovery, even after considering other factors such as age and existing health conditions.
COVID-19 and AKI: Where Do We Stand?
J Am Soc Nephrol
May 2021
Kidney Medicine Section, Medical Service, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania and Renal-Electrolye Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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