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A positive relationship between weight-adjusted waist index and non-alcoholic fatty liver disease: a study on US adolescents.
Front Med (Lausanne)
January 2025
Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Background: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition in children, underscoring the urgent need for non-invasive markers for early detection in this population.
Methods: We utilized survey data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020 regarding liver ultrasound transient elastography (LUTE) for the diagnosis of NAFLD (dependent variable), and used multiple logistic regression models to explore the association between weight-adjusted waist circumference index (WWI) and the prevalence of NAFLD in US adolescents. Smoothing curves and threshold effect analyses were used to assess the non-linear association between the independent variables and the dependent variable.
Potential diagnostic value of high b-value computed diffusion-weighted imaging in hepatocellular carcinoma.
Clin Exp Hepatol
March 2024
Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.
Aim Of The Study: Over the past few years, diffusion-weighted imaging (DWI) has become an increasingly important diagnostic tool in the diagnosis of liver lesions. The objective of the present study was to evaluate the diagnostic benefit of high b-value computed diffusion-weighted imaging (c-DWI) compared with standard DWI in patients with hepatocellular carcinoma (HCC) and whether there is an association with microvascular invasion (MVI).
Material And Methods: In total, 37 patients with histopathologically confirmed HCC were retrospectively ana-lyzed.
Assessment of serum Mac-2 binding protein glycosylation isomer as a potential marker for hepatocellular carcinoma in cirrhotic hepatitis C patients.
Clin Exp Hepatol
March 2024
Department of Tropical Medicine, Faculty of Medicine, Alexandria University, Egypt.
Aim Of The Study: To assess the serum level of Mac-2 binding protein glycosylation isomer as a potential biomarker for hepatocellular carcinoma (HCC) in hepatitis C virus (HCV) cirrhotic patients.
Material And Methods: Ninety patients were separated into two groups for the current research. Group I consisted of 45 patients with HCV that resulted in liver cirrhosis but no HCC.
Liver macrophage activation: Relation with hepatic histopathological changes in patients with metabolic associated steatotic liver disease.
Clin Exp Hepatol
March 2024
General Surgery Department, Hepatobiliary Surgery Unit, Faculty of Medicine, Alexandria University, Egypt.
Aim Of The Study: Metabolic associated steatotic liver disease (MASLD) is one of the most frequent chronic liver diseases in the world; macrophage activation is reflected by increased expression of CD163, which sheds as serum soluble CD163 that is linked to hepatic steatosis, inflammation, and fibrosis. Aim of the study was assessment of liver macrophage activation and hepatic histopathological changes in patients with MASLD.
Material And Methods: A total of 30 patients with MASLD and equal numbers of age- and sex-matched healthy controls were enrolled in the study.
Hepatobiliary Adverse Events Associated With the KRAS p.G12C Inhibitor Sotorasib.
Pharmacoepidemiol Drug Saf
February 2025
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Purpose: The p.G12C mutation in KRAS is commonly found in many cancers and was previously untreatable until drugs like sotorasib were developed. However, up to 15% of patients treated with sotorasib have experienced hepatobiliary adverse events.
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