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Biomarkers and Tourette syndrome: a systematic review and meta-analysis.
Front Neurol
February 2024
Department of Pediatrics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Objective: This research aims to investigate whether peripheral biomarkers might differentiate individuals with Tourette syndrome (TS) from those without the condition.
Methods: A broad range of databases was searched through November 2022. This study employed a systematic literature review and subsequent meta-analysis of case-control studies that assessed the aberration of biomarkers of patients with TS and controls.
Development and characterization of a hemolysis inhibition assay to determine functionality of anti-Streptolysin O antibodies in human sera.
J Immunol Methods
March 2024
GSK Vaccines Institute for Global Health (GVGH), GSK Global Health Vaccines R&D, via Fiorentina 1, 53100 Siena, Italy. Electronic address:
The high burden of disease and the long-lasting sequelae following Streptococcus pyogenes (Strep A) infections make the development of an effective vaccine a global health priority. Streptolysin O (SLO), is a key toxin in the complex pathogenesis of Strep A infection. Antibodies are elicited against SLO after natural exposure and represent a key target for vaccine-induced immunity.
View Article and Find Full Text PDFNarcolepsy type 1 and Sydenham chorea - Report of 3 cases and review of the literature.
Sleep Med
December 2023
Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Objectives/background: Narcolepsy type 1 (NT1) is an immune-mediated disorder characterized by excessive daytime sleepiness, cataplexy, low levels of hypocretin-1 in the cerebrospinal fluid, and a strong association with the HLA DQB1*06:02 allele. There is evidence for streptococcal infections as one pathogenic factor that may lead to NT1 as part of a multifactorial pathogenesis. Elevated titers of Antistreptolysin-O antibodies and increased inflammatory activity in response to streptococci antigens have been described in patients with NT1.
View Article and Find Full Text PDFSerological detection and genetic characterization of foot-and-mouth disease virus from cattle in northern sudan, 2016‑2018.
Vet Anim Sci
September 2021
Foot-and-Mouth-Disease Department, Central Veterinary Research Laboratory (CVRL), Soba, P.O. Box 8067, Al Amarat, Khartoum, Sudan.
Northern Sudan is an important corridor cluster between pools of foot-and-mouth disease virus (FMDV) in East and North Africa. It involves almost the whole border area with Egypt and represents a considerable part of a projected disease-free zone in Sudan. The study monitored FMD infection between 2016 and 2018 in Northern Sudan.
View Article and Find Full Text PDFImmunity and Gilles de la Tourette syndrome: A systematic review and meta-analysis of evidence for immune implications in Tourette syndrome.
Eur J Neurol
September 2021
Assistance Publique-Hôpitaux de Paris, Pôle de Psychiatrie, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Paris-East Créteil University, Créteil, France.
Background And Purpose: The neurobiology of Gilles de la Tourette syndrome (GTS) is known to involve corticostriatal loops possibly under genetic control. Less is known about possible environmental triggers of GTS. Specifically, immune-related events following possible environmental inducers have been evoked, but important controversies still exist.
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