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Alcohol consumption and incident heart failure in men and women.
Eur J Heart Fail
January 2025
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Aims: Regular heavy alcohol consumption may lead to the development of alcohol-related cardiomyopathy and symptomatic heart failure (HF) later in life. However, the dose-response relationship between alcohol consumption and risk for incident HF, and whether these associations vary by sex and type of alcoholic beverage remains unclear.
Methods And Results: A total of 407 014 participants (52% women, age 56 years) from the UK Biobank who completed alcohol-related questionnaires and without a history of HF at baseline were included in the study.
TFEB activator protects against ethanol toxicity-induced cardiac injury by restoring mitophagy and autophagic flux.
Biochim Biophys Acta Mol Basis Dis
January 2025
College of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China; The Key Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, China. Electronic address:
Excessive alcohol consumption is a major cause of alcoholic cardiomyopathy (ACM) and myocardial injury. This study aims to investigate the role of transcription factor EB (TFEB) in ethanol-induced cardiac anomalies using a murine model, AC16 human cardiomyocytes, and human plasma. Wild-type mice treated with a TFEB activator (Compound 1) or vehicle (25 mg/kg/d) were challenged with or without ethanol (3 g/kg/d, i.
View Article and Find Full Text PDFINFLUENCE OF VITAMIN E ON PANCREATIC ACINAR CELL MORPHOLOGY AND SERUM AMYLASE CONCENTRATIONS IN ALCOHOL-INDUCED PANCREATIC TOXICITY.
J Ayub Med Coll Abbottabad
December 2024
Department of Physiology.
Background: Misusing alcohol can cause damage to different tissues in the body, resulting in conditions like alcoholic liver disease, pancreatitis, cardiomyopathy, neurotoxicity, muscle wasting, weakened immune system, hormonal disruptions, birth defects, and bone loss. The objective of this research was to evaluate how alcohol affects the exocrine pancreas histology and the levels of amylase in the blood serum. Additionally, it aimed to explore whether vitamin E provides a safeguard against alcohol-induced harm to the pancreas in rabbits.
View Article and Find Full Text PDFNon-alcoholic fatty liver disease and LV diastolic dysfunction in patients with type 2 diabetes mellitus.
Caspian J Intern Med
October 2024
Department of Internal Medicine, School of Medicine, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran.
Article Synopsis
- - This study investigates the link between non-alcoholic fatty liver disease (NAFLD) and early left ventricular diastolic dysfunction (LVDD) in patients with type 2 diabetes mellitus (T2DM).
- - Conducted on ninety diabetic outpatients, the study did not find a significant association between NAFLD and LVDD progression, despite high rates of both conditions among participants.
- - The research highlights the importance of monitoring LVDD in diabetic patients with NAFLD to potentially prevent future heart complications, even without a direct correlation found between the two conditions.
Comprehensive Health Assessment Using Risk Prediction for Multiple Diseases Based on Health Checkup Data.
AJPM Focus
December 2024
NEC Solution Innovators, Ltd., Tokyo, Japan.
Article Synopsis
- The study aimed to create risk prediction models that estimate the likelihood of multiple diseases (heart, brain, liver, etc.) using only health checkup data for personalized healthcare strategies.
- Researchers analyzed health checkup data from over 92,000 individuals and developed models using Cox proportional hazard regression to predict disease risk based on various health metrics.
- The developed models showed strong predictive capabilities, with high area under the curve scores for several diseases, potentially aiding in early diagnosis and targeted prevention strategies.
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