In 12 rabbits with induced experimental Masugi nephritis and in 6 control rabbits the level of 5-HT in whole blood and 5-HIAA excretion in urine/24 h were studied. In all animals of the experimental group a significant increase of 5-HT and 5-HIAA was found, which was strictly correlated in time with two-phase immunological reaction occurring in Masugi nephritis. Moreover, the electorn microscope examinations showed a distinct thickening of glomerular basement membrane on the 8th day of experiment, i.e., at the time of maximum 5-HT increase in the blood, which according to the literature, can be interpreted as having been caused, if not exclusively, so at least among others, by direct action of endogenous 5-HT.
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