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Subunit-specific conductance of single homomeric and heteromeric HCN pacemaker channels at femtosiemens resolution.
Proc Natl Acad Sci U S A
February 2025
Institut für Physiologie II, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena 07740, Germany.
In mammals, the four subunit isoforms HCN1-4 assemble to form functional homotetrameric and heterotetrameric hyperpolarization-activated cyclic nucleotide-modulated (HCN) ion channels. Despite the outstanding relevance of HCN channels for organisms, including generating electrical rhythmicity in cardiac pacemaker cells and diverse types of brain neurons, key channel properties are still elusive. In particular, the unitary conductance, of HCN channels is highly controversial.
View Article and Find Full Text PDFRhodium-Catalyzed Homogeneous Asymmetric Hydrogenation of Naphthol Derivatives.
J Am Chem Soc
January 2025
National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, P. R. China.
Due to their strong aromaticity and difficulties in chemo-, regio-, and enantioselectivity control, asymmetric hydrogenation of naphthol derivatives to 1,2,3,4-tetrahydronaphthols has remained a long-standing challenge. Herein, we report the first example of homogeneous asymmetric hydrogenation of naphthol derivatives catalyzed by tethered rhodium-diamine catalysts, affording a wide array of optically pure 1,2,3,4-tetrahydronaphthols in high yields with excellent regio-, chemo-, and enantioselectivities (up to 98% yield and >99% ee). Mechanistic studies with experimental and computational approaches reveal that fluorinated solvent 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) plays vital roles in the control of reactivity and selectivity, and 1-naphthol is reduced via a cascade reaction pathway, including dearomative tautomerization, 1,4-hydride addition, and 1,2-hydride addition in sequence.
View Article and Find Full Text PDFRetrospective analysis of the effect of electronic cardiotocography on selected birth and neonatal variables among 4172 women from a Single Centre in Warsaw, Poland.
Ginekol Pol
January 2025
Department of Obstetrics and Gynecology Didactics, Faculty of Health Sciences, Medical University of Warsaw, Poland.
Objectives: Cardiotocography (KTG) is widely used for continuous or intermittent assessment of fetal heart function. This study aimed to compare the effects of continuous and intermittent KTG during labour on selected variables.
Material And Methods: In a retrospective study, 4172 medical records of Warsaw Hospital (Poland) patients were analysed.
"Breaking the Bleed" Spontaneous Hemorrhage in an Emphysematous Bulla Complicated by Anticoagulation: A Case Report.
Cureus
December 2024
Internal Medicine, Mercy Health St. Vincent Medical Center, Toledo, USA.
We present a case of spontaneous hemorrhage in an emphysematous bulla, complicated by anticoagulation. Bullous emphysema is a well-recognized complication of chronic obstructive pulmonary disease (COPD), and a rare manifestation is hemorrhage into preexisting pulmonary bullae. A 69-year-old male patient presented to the emergency department with hemoptysis, shortness of breath, and productive cough.
View Article and Find Full Text PDFDevelopment of a non-invasive heart rate measurement method for sea turtles with dense keratinous scutes through effective electrode placement.
Front Physiol
January 2025
Atmosphere and Ocean Research Institute, The University of Tokyo, Kashiwa, Japan.
Article Synopsis
- Measuring the heart rate of sea turtles helps us understand their physiological adaptations, particularly focusing on the non-invasive ECG methods developed for loggerhead turtles.
- The study explored alternative electrode placements on the plastron of green sea turtles, finding successful ECG readings when the negative electrode was positioned near the neck.
- Results showed that resting heart rates averaged about 8.6 beats per minute, aligning with previous studies, and highlight the need for careful individual selection to improve measurement reliability.
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