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Management of patient with acute lymphocytic myocarditis and congenital long QT syndrome presenting with electrical storm and incessant Torsade de Pointes: a case report.
J Med Case Rep
December 2024
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia.
Background: This case highlights the management of concomitant acute myocarditis and congenital long QT syndrome with electrical storm and incessant Torsade de Pointes.
Case Presentation: An 18 years-old Southeast Asian para 1 abortus 0 (P1A0) postpartum patient with cesarean section owing to severe preeclampsia, acute lymphocytic myocarditis, and prolonged QT interval owing to long QT syndrome. She has incessant Torsade de Pointes treated with beta-blocker, lidocaine, overdrive pacing with a temporary transvenous pacemaker, left cardiac sympathetic denervation per video-assisted thoracoscopic surgery, and implantable cardioverter-defibrillator implantation.
Sinoatrial node heterogeneity and fibroblasts increase atrial driving capability in a two-dimensional human computational model.
Front Physiol
July 2024
Department of Electrical, Electronic, and Information Engineering "Guglielmo Marconi", University of Bologna, Cesena, Italy.
Cardiac pacemaking remains an unsolved matter from many perspectives. Extensive experimental and computational studies have been performed to describe the sinoatrial physiology across different scales, from the molecular to clinical levels. Nevertheless, the mechanism by which a heartbeat is generated inside the sinoatrial node and propagated to the working myocardium is not fully understood at present.
View Article and Find Full Text PDFImpulse initiation in engrafted pluripotent stem cell-derived cardiomyocytes can stimulate the recipient heart.
Stem Cell Reports
August 2024
Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Germany; Cardiovascular Regeneration Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain. Electronic address:
Transplantation of pluripotent stem cell-derived cardiomyocytes is a novel promising cell-based therapeutic approach for patients with heart failure. However, engraftment arrhythmias are a predictable life-threatening complication and represent a major hurdle for clinical translation. Thus, we wanted to experimentally study whether impulse generation by transplanted cardiomyocytes can propagate to the host myocardium and overdrive the recipient rhythm.
View Article and Find Full Text PDFTransvenous Pacemaker Placement: A Review for Emergency Clinicians.
J Emerg Med
April 2024
Department of Emergency Medicine, Rush University, Chicago, Illinois.
Article Synopsis
- Transvenous pacemaker placement is a critical skill in emergency medicine, used for treating severe heart rhythm issues like bradycardia and tachydysrhythmias.
- The procedure involves placing a pacing wire through a central venous catheter into the right ventricle, with guidance from ultrasound to ensure correct positioning.
- While it can be life-saving, clinicians must be aware of potential complications during the procedure and develop troubleshooting strategies if the pacemaker doesn’t work immediately.
Monolithic silicon for high spatiotemporal translational photostimulation.
Nature
February 2024
The James Franck Institute, The University of Chicago, Chicago, IL, USA.
Electrode-based electrical stimulation underpins several clinical bioelectronic devices, including deep-brain stimulators and cardiac pacemakers. However, leadless multisite stimulation is constrained by the technical difficulties and spatial-access limitations of electrode arrays. Optogenetics offers optically controlled random access with high spatiotemporal capabilities, but clinical translation poses challenges.
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