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An integrated study of hard and soft cluster analyses for detecting leachate in a MSW landfill site using geoelectrical data.
Waste Manag
January 2025
Dipartimento di Scienze della Terra, dell'Ambiente e delle Risorse (DiSTAR), Università degli Studi di Napoli "Federico II", Naples, Italy. Electronic address:
An accurate assessment of leachate levels necessitates the integration of various parameters. Traditional geophysical prospecting methods often lack measurable accuracy because they focus on individual parameters rather than effectively integrating data. This may lead to inconsistent estimates of leachate depth and make the evaluation of prediction reliability challenging.
View Article and Find Full Text PDFNatural Products Analysis Through Time: From Past Achievements to Future Prospects.
Methods Mol Biol
January 2025
Natural Products Lab, Institute of Biology, Leiden University, Leiden, The Netherlands.
This introductory chapter traces the evolution of (bio)chemical assays, emphasizing the critical role of robust protocols in ensuring reproducibility-a fundamental aspect of scientific research. With the advent of systems biology, the need for standardized methods has intensified, particularly for integrating vast datasets in open-access formats. The historical progression from basic plant morphology to advanced chromatographic and spectroscopic techniques in phytochemistry highlights the necessity for precise, reproducible protocols.
View Article and Find Full Text PDFRecent Advances of Gaseous Pollutant Catalytic Oxidation over Precious Metal Catalysts with SO Exposure.
Environ Sci Technol
January 2025
Tianjin Key Lab of Indoor Air Environmental Quality Control, School of Environmental Science and Technology, Tianjin University, Tianjin 300350, China.
Precious metal catalysts are widely used for catalytic oxidation of various gaseous pollutants (CO, methane, and VOCs) due to their excellent catalytic activity. However, they are easily affected by SO and deactivated in actual industrial waste gas or motor vehicle exhaust. Therefore, this review systematically summarizes the representative studies of gaseous pollutant catalytic oxidation over precious metal catalysts with SO exposure.
View Article and Find Full Text PDFUltrasound-Activated Copper Matrix Nanosonosensitizer for Cuproptosis-Based Synergy Therapy.
ACS Appl Bio Mater
January 2025
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.
Cuproptosis exhibits enormous application prospects in treatment. However, cuproptosis-based therapy is impeded by the limited intracellular copper ions, the nonspecific delivery, uncontrollable release, and chelation of endogenous overproduced glutathione (GSH). In this work, an ultrasound-triggered nanosonosensitizer (p-TiO-Cu(I)) was constructed for Cu(I) delivery, on-demand release, GSH consumption, and deeper tissue response.
View Article and Find Full Text PDFProgress and prospects in antisense oligonucleotide-mediated exon skipping therapies for Duchenne muscular dystrophy.
J Muscle Res Cell Motil
January 2025
Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK.
Recent years have seen enormous progress in the field of advanced therapeutics for the progressive muscle wasting disease Duchenne muscular dystrophy (DMD). In particular, four antisense oligonucleotide (ASO) therapies targeting various DMD-causing mutations have achieved FDA approval, marking major milestones in the treatment of this disease. These compounds are designed to induce alternative splicing events that restore the translation reading frame of the dystrophin gene, leading to the generation of internally-deleted, but mostly functional, pseudodystrophin proteins with the potential to compensate for the genetic loss of dystrophin.
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