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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of California, Irvine, Irvine, CA, USA.
Background: Recent studies have suggested a transient glucose hypermetabolism in early phases of Alzheimer's Disease (AD), which is followed by a characteristic glucose hypometabolism in dementia stages. This phenomenon desveres further investigation and it is suggested to be associated to glial/inflammatory or compensatory neuronal responses. Here, we aimed to longitudinally investigate brain glucose metabolism in an AD animal model and explore associated cellular and inflammatory changes.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Background: Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a neuropathologically-defined disease, and it is frequently comorbid with Alzheimer's disease neuropathological change (ADNC). However, the neurological syndrome associated with LATE neuropathological change (LATE-NC) is not defined. We propose a set of clinical criteria for a limbic-predominant amnestic neurodegenerative syndrome (LANS) that is highly associated with LATE-NC.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Fleni, Buenos Aires, Buenos Aires, Argentina.
Background: Surface dyslexia serves as a complementary feature in the classification of the semantic variant of Primary Progressive Aphasia (PPA), while reading deficits have also been reported in the other two PPA variants. In opaque languages, tasks involving regular and irregular words and non-words are useful tools for dyslexia diagnosis. However, in transparent languages like Spanish, where most words are regular for reading, different approaches are needed.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France.
Background: Anosognosia, a hallmark of Alzheimer's disease (AD), manifests as a gradual decline in disease awareness, yet its neural correlates remain unclear. This study investigates how amyloid accumulation, glucose hypometabolism and cortical atrophy relate to cognitive awareness across the AD continuum. Both the pathological processes and the brain regions involved were studied.
View Article and Find Full Text PDFNuclear Medicine Imaging in Epilepsy.
Radiographics
January 2025
From the Department of Radiology, University of Cincinnati Medical Center, 3188 Bellevue Ave, Cincinnati, OH 45219 (A.S., A.T.T., B.W.M., L.L.W., J.L.S.); and Department of Radiology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH (A.T.T.).
Approximately one-third of patients with focal epilepsy have medically refractory focal epilepsy (MRFE), which significantly impacts their quality of life. Once a seizure focus is identified and determined to be in the noneloquent cortex, it can be surgically resected with the goal of freedom from seizures and minimal neurocognitive deficit. During noninvasive (phase I) presurgical planning, functional (nuclear) imaging and structural imaging are complementary in the accurate localization of the epileptogenic zone (EZ).
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