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Estimation of dose to a bystander from F-18 FDG patients using Monte Carlo simulation in clinical exposure scenarios.
Phys Eng Sci Med
January 2025
Department of Physics and Radiation Safety, Nepean Hospital, Penrith, New South Wales, Australia.
The radiation exposure to bystanders from nuclear medicine patients is a common concern raised in nuclear medicine departments. The GATE (Geant4 Application for Tomographic Emission) Monte Carlo radiation transport application was used to estimate the dose to a bystander. Two voxelised phantoms were utilised in a GATE Monte Carlo simulation as the radiation source and target.
View Article and Find Full Text PDF[Measurement of Airborne Radioactivity in the Inpatient Room after Administering [Cu]Cu-ATSM to Patients].
Kaku Igaku
January 2025
Department of Radiology, Kindai University Faculty of Medicine.
Objective: [Cu]Cu-ATSM is a radiotherapeutics under clinical trials. It is necessary to take appropriate measures to limit its exposure and ensures its airborne concentrations do not exceed legally permitted levels. Therefore, the purpose of this study was to measure the airborne radioactivity concentration in the inpatient room after administering [Cu]Cu-ATSM to patients.
View Article and Find Full Text PDFTowards the Stable Chelation of Radioantimony(V) for Targeted Auger Theranostics.
Angew Chem Int Ed Engl
January 2025
Oak Ridge National Laboratory, Chemical Sciences Division, UNITED STATES OF AMERICA.
Antimony-119 (119Sb) is one of the most attractive Auger-electron emitters identified to date, but it remains practically unexplored for targeted radiotherapy because no chelators have been identified to stably bind this metalloid in vivo. In a departure from current studies focused on chelator development for Sb(III), we explore the chelation chemistry of Sb(V) using the tris-catecholate ligand TREN-CAM. Through a combination of radiolabeling, spectroscopic, solid-state, and computational studies, the radiochemistry and structural chemistry of TREN-CAM with 1XX/natSb(V) were established.
View Article and Find Full Text PDFEffectiveness and safety of radionuclide synovectomy with Yttrium-90 hydroxyapatite in patients with inflammatory arthritis: a longitudinal study.
Nucl Med Commun
January 2025
Department of Pharmacology.
Background And Objective: Yttrium-90 plays a significant role in managing drug-resistant inflammatory arthritis through radionuclide synovectomy, where the radioisotope is injected into the affected joint to alleviate pain and inflammation by targeting the synovial tissue. This study aims to evaluate the effectiveness and safety of Yttrium-90 hydroxyapatite radionuclide synovectomy in improving joint functionality, as judged by physicians, in patients with inflammatory arthritis who had not responded to conventional treatments.
Methods: Patients with inflammatory arthritis were recruited from the orthopedics department and referred to the nuclear medicine department for evaluation.
Investigating the significance of SPECT/CT-SUV for monitoring Lu-PSMA-targeted radionuclide therapy: a systematic review.
BMC Med Imaging
January 2025
Department of Radiological Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Background: Quantitative molecular imaging via single-photon emission computed tomography-derived standardised uptake value (SPECT/CT-SUV) is used to assess the response of metastatic castration-resistant prostate cancer (mCRPC) patients to targeted radionuclide therapy (TRT) with [Lu]Lu-PSMA. This imaging technique determines the radiopharmaceutical distribution and internal dosimetry in patients who receive TRT. However, there is limited evidence regarding the role of image quantification in monitoring changes induced by [Lu]Lu-PSMA.
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