A case is described of severe recurrent ischaemic heart disease associated with rapidly increasing and ultimately massive hyperlipidaemia. The case is discussed, with suggestions for management of similar problems.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425589 | PMC |
http://dx.doi.org/10.1136/pgmj.55.644.416 | DOI Listing |
Int J Mol Sci
March 2025
Institute of Cardiology, Lithuanian University of Health Sciences, Sukileliu 15, 50103 Kaunas, Lithuania.
Hypercholesterolemia, characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C), along with inflammation, is a well-known risk factor for developing atherosclerosis and coronary artery disease (CAD). Many patients with hypercholesterolemia may carry inherited genetic variants that are not part of the commonly recognized mutations in the , , , and genes. These genetic variants may have cumulative effects that contribute to increased LDL-C levels and CAD development.
View Article and Find Full Text PDFCureus
February 2025
Internal Medicine-Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, USA.
Cholesterol emboli syndrome is a rare syndrome of tissue ischemia and necrosis caused by the embolization of cholesterol crystals from atherosclerotic plaques, leading to vascular occlusion. This report documents a case of cholesterol emboli syndrome in a 72-year-old male with multiple cardiovascular risk factors including end-stage renal disease, atrial fibrillation, hypertension, hyperlipidemia, and type 2 diabetes. We describe this patient's atypical presentation with upper extremity rather than lower extremity digital ischemia as a presenting sign and significant subsequent functional decline exacerbated by his comorbidities.
View Article and Find Full Text PDFCureus
February 2025
Internal Medicine, St. Luke's University Health Network, Easton, USA.
Anti-N-methyl-d-aspartate receptor encephalitis (NMDARE) is an autoimmune disorder with a clinical presentation that overlaps with that of a myriad of neuropsychiatric conditions. Delays in diagnosis have been linked to long-term complications that affect a patient's quality of life. A 60-year-old female patient with a medical history of emphysema with chronic respiratory failure, hypertension, diabetes, morbid obesity, and hyperlipidemia presented to the hospital after she was found confused at home with limited verbal output, raising concerns for cerebrovascular events or toxic metabolic encephalitis.
View Article and Find Full Text PDFHepatitis B is a major health concern. It primarily affects the liver, but it can also cause systemic complications like antigenaemia and nephrotic syndrome. Nephrotic syndrome causes proteinuria, hypoalbuminaemia, oedema, hyperlipidaemia and hypercoagulability.
View Article and Find Full Text PDFSwiss Med Wkly
February 2025
Department of Cardiology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
We present the first case in Switzerland of a patient with homozygous familial hypercholesterolaemia treated with evinacumab, a new recombinant human monoclonal antibody currently approved in Europe and in the USA but not yet in Switzerland. Homozygous familial hypercholesterolaemia is a rare genetic disorder that causes severely elevated levels of low-density lipoprotein (LDL) cholesterol and early atherosclerotic cardiovascular disease, which, if left untreated, can lead to premature death. As a result of this newly introduced treatment, the patient's LDL cholesterol levels were reduced by more than half, achieving recommended target values of secondary prevention for the first time.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!