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Endostatin as a biomarker of systemic sclerosis: insights from a systematic review and meta-analysis.
Front Immunol
January 2025
Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Introduction: The critical role played by vascular dysfunction and ineffective angiogenesis in the pathophysiology of systemic sclerosis (SSc) suggests that circulating biomarkers reflecting these alterations may be useful in the clinical evaluation of this patient group. We sought to address this issue by conducting a systematic review and meta-analysis of studies investigating a such candidate biomarker, endostatin, an endogenous glycoprotein exerting anti-angiogenic effects, in SSc patients and healthy controls.
Methods: A literature search was conducted in the electronic databases Web of Science, PubMed, and Scopus from inception to 27 May 2024.
Use of nailfold capillaroscopy for the assessment of patients undergoing digit replantation and revascularization.
Jt Dis Relat Surg
January 2025
İnönü Üniversitesi Tıp Fakültesi Turgut Özal Tıp Merkezi, Ortopedi ve Travmatoloji Anabilim Dalı, 44280 Malatya, Türkiye.
Objectives: In this study, we aimed to evaluate microvascular changes using nailfold capillaroscopy in patients who underwent digit replantation and revascularization.
Patients And Methods: A total of 46 patients (34 males, 12 females; mean age: 45.8±17.
Assessment of Microcirculation and Microrheological Parameters of Blood in Patients With Type 2 Diabetes Mellitus Using Biophotonics Techniques.
J Biophotonics
December 2024
Department of Physics, Lomonosov Moscow State University, Moscow, Russia.
In this study, the parameters of blood microcirculation and microrheology were measured using the methods of laser aggregometry and optical tweezers in vitro, as well as the method of digital capillaroscopy in vivo. It was shown that in patients suffering from type 2 diabetes mellitus, an increase in the number of RBC aggregates passing through the narrow capillaries leads to a significant decrease in the velocity of the capillary blood flow, which can be explained by the increased viscosity of the whole blood and decreased deformability of RBCs. Also, for the group of patients, a statistically significant increase in the rate of RBC aggregation and the hydrodynamic strength of aggregates, RBC aggregation and disaggregation forces were observed compared to the control group.
View Article and Find Full Text PDFVascular endothelial growth factor as a potential biomarker in systemic sclerosis: a systematic review and meta-analysis.
Front Immunol
December 2024
Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Introduction: Systemic sclerosis (SSc), a chronic autoimmune condition, is characterized by microvascular dysfunction, ineffective angiogenesis, and fibrosis. The identification of robust biomarkers reflecting these processes may assist in clinical management and lead to the discovery of new therapies. We sought to address this issue by conducting a systematic review and meta-analysis of studies investigating one such biomarker, vascular endothelial growth factor (VEGF), in SSc patients and healthy controls and in SSc patients with localized or diffuse disease, different video capillaroscopy patterns (early, active, or late), and presence or absence of complications.
View Article and Find Full Text PDFNailfold capillaroscopic assessment in pediatric patients with autoimmune uveitis: a case-control study.
Clin Rheumatol
December 2024
Department of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Article Synopsis
- Uveitis is a significant cause of visual impairment, often stemming from autoimmune conditions, and can occur in children either as part of other systemic diseases or on its own.
- The study evaluated 25 pediatric patients with autoimmune uveitis and 21 healthy children using nailfold capillaroscopy to assess systemic microcirculation, focusing on capillary density and morphology.
- Results indicated that children with autoimmune uveitis had a significantly lower capillary density compared to healthy peers, suggesting potential systemic involvement, even in isolated cases.
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