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Longitudinal and Noninvasive Intracellular Recordings of Spontaneous Electrophysiological Activity in Rat Primary Neurons on Planar MEA Electrodes.
Adv Mater
January 2025
Italian Institute of Technology, Genoa, 16163, Italy.
Presently, the in vitro recording of intracellular neuronal signals on microelectrode arrays (MEAs) requires complex 3D nanostructures or invasive and approaches such as electroporation. Here, it is shown that laser poration enables intracellular coupling on planar electrodes without damaging neurons or altering their spontaneous electrophysiological activity, allowing the process to be repeated multiple times on the same cells. This capability distinguishes laser-based neuron poration from more invasive methods like electroporation, which typically serve as endpoint measurement for cells.
View Article and Find Full Text PDFVisualization of primary afferent-evoked excitation of spinal dorsal horn neurons using an intracellular Ca imaging technique in adult rat spinal cord slices.
J Anesth
January 2025
Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Science, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Article Synopsis
- This study developed a method for intracellular calcium imaging in adult rat spinal cord slices to understand neuronal activity better.
- The research found that the type of stimulation used (A-fiber vs. C-fiber) affected the calcium responses, with different intensity levels leading to distinct response patterns.
- Results showed that certain drugs, like morphine, significantly suppressed calcium responses, while others, like bicuculline and high doses of tranexamic acid, enhanced them, allowing for insights into pain transmission and modulation in the spinal cord.
Activation thresholds for electrical phrenic nerve stimulation at the neck: evaluation of stimulation pulse parameters in a simulation study.
J Neural Eng
November 2024
Institute of Biomedical Engineering and Informatics, TU Ilmenau, Ilmenau, Germany.
Phrenic nerve stimulation reduces ventilator-induced-diaphragmatic-dysfunction, which is a potential complication of mechanical ventilation. Electromagnetic simulations provide valuable information about the effects of the stimulation and are used to determine appropriate stimulation parameters and evaluate possible co-activation.Using a multiscale approach, we built a novel detailed anatomical model of the neck and the phrenic nerve.
View Article and Find Full Text PDFPost-procedural Brachial Neuritis: Clinical, Electrodiagnostic and Neuroimaging features.
AJNR Am J Neuroradiol
November 2024
From the School of Medicine (V.S.A), Department of Neurology (N.M., N.A., A.N.P, B.R.B, R.P.K), Department of Neurological Surgery (V.S.A., P.V.M), and Department of Radiology and Biomedical Imaging (V.N.S), Neuroradiology Section, University of California, San Francisco, San Francisco, California, USA.
Background And Purpose: Brachial neuritis is a monophasic condition affecting the brachial plexus and its branches, manifesting as acute shoulder and upper arm pain, followed by weakness and paresthesias. It can be triggered by antecedent events, including procedures such as surgery. Misdiagnosis and delay in diagnosis is common.
View Article and Find Full Text PDFArrhythmogenicity of monophasic and biphasic PFA waveforms in a porcine model.
J Cardiovasc Electrophysiol
December 2024
Medtronic, Minneapolis, Minnesota, USA.
Objective: The potential risk of inducing ventricular arrhythmias was explored by employing pulsed field ablation (PFA) through the administration of both monophasic and biphasic waveform deliveries.
Methods: PFA was applied to specific locations in the right ventricle (RV, n = 5 sites) in swine (n = 2), utilizing identical settings with consistent amplitude, pulse width, and a number of pulses for both monophasic and biphasic waveforms. PFA deliveries were precisely timed in 10-ms intervals across the entire T wave.
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