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Repetitive transcranial magnetic stimulation for fibromyalgia: are we there yet?
Pain Rep
February 2025
Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.
Repetitive transcranial magnetic stimulation (rTMS) has increasingly been used to modify cortical maladaptive plastic changes shown to occur in fibromyalgia (FM) and to correlate with symptoms. Evidence for its efficacy is currently inconclusive, mainly due to heterogeneity of stimulation parameters used in trials available to date. Here, we reviewed the current evidence on the use of rTMS for FM control in the format of a narrative review, in which a systematic dissection of the different stimulation parameters would be possible.
View Article and Find Full Text PDFGlobal Trends in the Incidence and Primary Causes of Femoral Fractures, Excluding Femoral Neck Fractures: A Global Epidemiological Study.
Risk Manag Healthc Policy
January 2025
Department of Orthopaedics and Joints, Huangyan Hospital of Traditional Chinese Medicine, Taizhou, 318020, People's Republic of China.
Purpose: Fractures pose a significant global health challenge, with varying incidence trends and causes across demographics and regions. This study aims to analyze global patterns in the incidence and primary causes of femoral shaft fractures.
Methods: Data from the Global Burden of Disease database were analyzed for femoral fractures (excluding femoral neck fractures) by age, gender, and socio-demographic index regions.
Revisiting the unobtrusive role of exogenous stem cells beyond neural circuits replacement in spinal cord injury repair.
Theranostics
January 2025
Department of biochemistry and molecular biology, College of Life Sciences, Central South University, Changsha, 410078, Hunan, China.
Stem cell transplantation is a promising strategy to establish neural relays in situ for spinal cord injury (SCI) repair. Recent research has reported short-term survival of exogenous cells, irrespective of immunosuppressive drugs (ISD), results in similar function recovery, though the mechanisms remain unclear. This study aims to validate this short-term repair effect and the potential mechanisms in large animals.
View Article and Find Full Text PDFExit interviews from two randomised placebo-controlled phase 3 studies with caregivers of young children with autism spectrum disorder.
Front Child Adolesc Psychiatry
June 2024
IM Franchise Department, Les Laboratoires SERVIER, Global Value, Access & Pricing, Suresnes, France.
Introduction: Autism spectrum disorder (ASD) is characterised by difficulty with social communication and restricted, repetitive patterns of behaviour. This study aimed to improve understanding of the ASD patient experience with the treatment (bumetanide) regarding the changes in core symptoms and to assess changes considered as meaningful. To achieve this, qualitative interviews were conducted with caregivers of patients in two phase 3 clinical trials (NCT03715153; NCT03715166) of a novel ASD treatment.
View Article and Find Full Text PDFImplications of Hemispheric Shift of Sensory Feedback during Post-stroke Motor Control on Personalized Stroke Rehabilitation.
Converg Clin Eng Res Neurorehabilit V (2024)
December 2024
University of Illinois Urbana-Champaign, Urbana, IL, USA; Carle Foundation Hospital, Urbana, IL, USA; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL 60611, USA.
Sensory feedback is crucial for motor control as it establishes the internal representation of motion. This study investigates changes in sensory feedback in hemiparetic stroke by analyzing the laterality index (LI) of somatosensory evoked potentials (SEPs) during movements of the paretic arm, focusing on a shift from the lesioned to the contralesional hemisphere. Three chronic stroke participants performed isometric lifts of their paretic arms at two different levels of their maximum voluntary contraction while receiving tactile finger stimulation.
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