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[ (Blume) Miq] maintains uric acid homeostasis via regulating gut microbiota and restrains renal inflammation in hyperuricemic nephropathy.
Front Pharmacol
November 2024
State key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Introduction: The kidney damage caused by the deposition of uric acid in the kidneys is of urgent need for new treatment drugs due to its complex pathogenesis. (Blume) Miq. Also known as , which has a significant therapeutic effect on hyperuricemia nephropathy (HN), however, the specific mechanism of its action is still unknown.
View Article and Find Full Text PDFProlonged Antibiotic Use in a Preclinical Model of Gulf War Chronic Multisymptom-Illness Causes Renal Fibrosis-like Pathology via Increased micro-RNA 21-Induced PTEN Inhibition That Is Correlated with Low Host Abundance.
Cells
December 2023
Environmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.
Article Synopsis
- Gulf War veterans face gastrointestinal issues and gut health imbalances, potentially linked to long-term antibiotic use, which may worsen these problems.
- A study using a mouse model found that prolonged antibiotic treatment led to increased kidney inflammation and specific molecular changes, indicating a risk of renal issues.
- The research suggests that gut health and inflammatory pathways in the kidneys are interconnected, highlighting a complex relationship between Gulf War Illness, antibiotics, and kidney damage through specific signaling mechanisms.
Molecular detection of multidrug-resistant Pseudomonas aeruginosa of different avian sources with pathogenicity testing and in vitro evaluation of antibacterial efficacy of silver nanoparticles against multidrug-resistant P. aeruginosa.
Poult Sci
October 2023
Department of Breast Care Surgery, the First Affiliated Hospital of clinical Medicine of Guangdong Pharmaceutical University, Guangzhou 510080, China.
Article Synopsis
- Pseudomonas aeruginosa (P. aeruginosa) is a significant pathogen in the poultry industry, leading to severe economic losses, and this study focused on isolating and identifying it from various avian sources in Egypt.
- The research identified highly resistant strains of P. aeruginosa from birds and eggs, confirming resistance to multiple antibiotics and detecting specific resistant genes associated with increased pathogenicity.
- An in vitro experiment indicated that silver nanoparticles (Ag-NPs) could be effective against these resistant strains, which were shown to cause serious health issues and tissue damage in affected birds.
Essential role of Wtip in mouse development and maintenance of the glomerular filtration barrier.
Am J Physiol Renal Physiol
September 2022
Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Wilms' tumor interacting protein (Wtip) has been implicated in cell junction assembly and cell differentiation and interacts with proteins in the podocyte slit diaphragm, where it regulates podocyte phenotype. To define Wtip expression and function in the kidney, we created a -deleted mouse model using β-galactosidase-neomycin (β-geo) gene trap technology. gene trap mice were embryonic lethal, suggesting additional developmental roles outside kidney function.
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