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Reduced-intensity chemotherapy with tyrosine kinase inhibitor followed by allogeneic transplantation is effective in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
Korean J Intern Med
January 2025
Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.
Background/aims: To determine the effectiveness of tyrosine kinase inhibitor (TKI) plus reduced-intensity therapy in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL), this retrospective study compared treatment outcomes and induction mortality according to backbone regimen intensity.
Methods: The data of 132 patients diagnosed with Ph-positive ALL were retrospectively collected from five centers. Patients received imatinib plus intensive chemotherapy (modified VPD, KALLA1407, or hyper-CVAD) or reduced-intensity chemotherapy (EWALL) for curative purposes.
A Review on Imaging in Axial Spondyloarthritis: SPARTAN 2024 Annual Meeting Proceedings.
Curr Rheumatol Rep
January 2025
Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Purpose Of Review: The purpose of this publication is to review the role of imaging in axial spondyloarthritis. These findings were presented at the SPARTAN annual meeting in May 2024.
Recent Findings: Imaging plays a major role in the diagnosis and monitoring of axial spondyloarthritis.
The Role of Pet-Based Activities: Working with Rabbits to Improve Self-Esteem in Preschool Children.
Animals (Basel)
December 2024
School of Animal Life Science, Hankyong National University, 327, Jungang-ro, Anseong-si 17579, Gyeongggi-do, Republic of Korea.
Animal-assisted activities (AAAs) effectively improve the self-esteem of infants and young children, thereby playing a significant role in their growth into adolescence. In particular, in modern society, self-esteem during childhood and adolescence can influence self-esteem during adulthood. Therefore, this study evaluates whether animal-assisted activities could improve infants' self-esteem.
View Article and Find Full Text PDFIdentification of core genes related to exosomes and screening of potential targets in periodontitis using transcriptome profiling at the single-cell level.
BMC Oral Health
January 2025
Department of Stomatology, People's Hospital of Xinjiang Autonomous Region, Urumqi City, China.
Background: The progression and severity of periodontitis (PD) are associated with the release of extracellular vesicles by periodontal tissue cells. However, the precise mechanisms through which exosome-related genes (ERGs) influence PD remain unclear. This study aimed to investigate the role and potential mechanisms of key exosome-related genes in PD using transcriptome profiling at the single-cell level.
View Article and Find Full Text PDFExtended 72-hour patency capsule protocol improves functional patency rates in high-risk patients undergoing capsule endoscopy.
World J Gastrointest Endosc
December 2024
Trinity Academic Gastroenterology Group, School of Medicine - Trinity College Dublin, Dublin 24 D24 NR0A, Ireland.
Background: Capsule endoscopy (CE) is a pivotal diagnostic tool for gastrointestinal (GI) disorders, yet capsule retention poses a significant risk, especially in patients with known risk factors. The patency capsule (PC) helps assess the functional patency of the GI tract to mitigate this risk. However, the standard 28-hour protocol for confirming patency often results in high false-positive rates, unnecessarily excluding many patients from undergoing diagnostic CE.
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