The post-surgical radiotherapy of breast cancer and its problems are discussed and an account is given of recent trends in this field. The use of fast electrons is regarded as an optimal form of management for the chest wall, and the ipsilateral subscapular and internal mammary lymph gland chains.
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RNA Translocation through Protein Nanopores: Interlude of the Molten RNA Globule.
J Am Chem Soc
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Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, United States.
Direct translocation of RNA with secondary structures using single-molecule electrophoresis through protein nanopores shows significant fluctuations in the measured ionic current, in contrast to unstructured single-stranded RNA or DNA. We developed a multiscale model combining the oxRNA model for RNA with the 3-dimensional Poisson-Nernst-Planck formalism for electric fields within protein pores, aiming to map RNA conformations to ionic currents as RNA translocates through three protein nanopores: α-hemolysin, CsgG, and MspA. Our findings reveal three distinct stages of translocation (pseudoknot, melting, and molten globule) based on contact maps and current values.
View Article and Find Full Text PDFRelationship Between Pituitary Gland and Stem Cell in the Aspect of Hormone Production and Disease Prevention: A Narrative Review.
Endocr Metab Immune Disord Drug Targets
January 2025
Amity Institute of Pharmacy, Amity University Haryana Chemistry Gurugram India.
Objectives: In the last two decades, scientists have gained a better understanding of several aspects of pituitary development. The signaling pathways that govern pituitary morphology and development have been identified, and the compensatory relationships among them are now known.
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Neutrophil Elastase as A Potential Target in Ischemia-Reperfusion Injury.
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View Article and Find Full Text PDF[Introduction of the Low and Medium Security Psychiatry Unit at the Nyírô Gyula National Institute of Psychiatry and Addictology].
Psychiatr Hung
January 2025
Országos Pszichiátriai és Addiktológiai Intézet, Budapest, Hungary, E-mail:
Under the direction of the National Directorate General for Hospitals, and based on British examples and methodology, a new inpatient psychiatric ward with a high security level started operating at the National Institute of Psychiatry and Addictology in October 2023. As a new, independent unit, the High Security Psychiatry is a niche in Hungarian psychiatric care. The aim of the project was to reduce the burden on the whole mental health care system in Hungary, to increase public confidence in care and the safety of society through organizing of a specialised care team operating in an appropriate infrastructural environment.
View Article and Find Full Text PDF3D Printed Titanium Scaffolds with Bi-Directional Gradient QK-Functionalized Surface.
Adv Mater
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National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China.
3D printed titanium scaffold has promising applications in orthopedics. However, the bioinert titanium presents challenges for promoting vascularization and tissue growth within the porous scaffold for stable osteointegration. In this study, a modular porous titanium scaffold is created using 3D printing and a gradient-surface strategy to immobilize QK peptide on the surface with a bi-directional gradient distribution.
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