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The microcirculation : master in normal pregnancy, puppet in preeclampsia.
Am J Obstet Gynecol
January 2025
Hasselt University, Faculty of Medicine and Life Sciences, Agoralaan, 3590 Diepenbeek, Belgium; Department of Obstetrics and Gynaecology, ZOL Genk, campus St. Jan, Schiepse Bos 6, 3600 Genk, Belgium.
Objective: To investigate the association between functional parameters of the microcirculation and the systemic cardiovascular system in a population of pregnant women at risk for gestational hypertension disorders.
Study Design: For this observational study, women at high cardiovascular risk according to maternal anthropometrics, obstetric and medical history, were recruited at random gestational age depending on time of referral to the outpatient clinic for high risk prenatal care at Ziekenhuis Oost Limburg, Genk Belgium. After birth, data of maternal and neonatal outcome were obtained from the hospital records: only women with normal pregnancy (n = 142) and with preeclampsia (n = 34) were included in this analysis.
Effects of Age and Sex on Systemic Inflammation and Cardiometabolic Function in Individuals With Type 2 Diabetes.
J Am Heart Assoc
January 2025
Rongxiang Xu Center for Regenerative Therapeutics, Microcirculation Lab, Beth Israel Deaconess Medical Center Harvard Medical School Boston MA.
Background: Systemic inflammation, aging, and type 2 diabetes (T2D) lead to varying degrees of cardiovascular dysfunction and impaired aerobic exercise capacity. This study evaluates the impact of inflammation and sex differences on coronary and peripheral vascular function and exercise capacity in older individuals with and without T2D.
Methods: Older individuals (aged≥65 years) underwent biochemical and tissue inflammatory phenotyping, cardiopulmonary exercise testing, cardiovascular magnetic resonance imaging, and vascular reactivity testing.
The association of capillary refill time and return of spontaneous circulation during out-of-hospital cardiac arrest: an observational study.
Crit Care
January 2025
Emergency Medical Service Vienna, Vienna, Austria.
Introduction: Microcirculatory alterations are predictive of poor outcomes in patients with shock and after cardiac arrest in animal models. However, microcirculatory alterations during human cardiac arrest have not yet been studied.
Methods: We prospectively included adult patients receiving resuscitation after witnessed out-of-hospital cardiac arrest.
Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy.
Plast Reconstr Surg Glob Open
January 2025
From the Department of Urology, Showa University School of Medicine; Tokyo, Japan.
Background: Chemotherapy-induced peripheral neuropathy (CIPN) affects 29%-68% of patients undergoing anticancer treatments within the first month. Traditional cryotherapy methods, such as frozen gloves, can pose risks. This study evaluates the cool-water electric circulation seat (CECS), which maintains a constant 15°C, as a safer alternative.
View Article and Find Full Text PDFICAM1 blockade improves ischemic muscle reperfusion in diabetic mice.
Cardiovasc Diabetol
January 2025
Univ. Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, CHU de Bordeaux, 1, Avenue de Magellan, Entrée par l'Hôpital Haut-Lévêque, 33604, Pessac, France.
Background: Chronic Limb-Threatening Ischemia (CLTI) represents the most advanced stage of Peripheral Artery Disease (PAD) and is associated with dire prognosis, characterized by a substantial risk of limb amputation and diminished life expectancy. Despite significant advancements in therapeutic interventions, the underlying mechanisms precipitating the progression of PAD to CLTI remain elusive.
Methods: Considering diabetes is one of the main risk factors contributing to PAD exacerbation into CLTI, we compared hind limb ischemia recovery in HFD STZ vs.
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