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β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during Collagen-Induced Arthritis.
Biomedicines
August 2022
Department of Rheumatology, Hiller Research Center Rheumatology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.
The sympathetic nervous system (SNS) has either a pro-inflammatory or anti-inflammatory effect, depending on the stage of arthritis. In the past, treatment of arthritic B cells with a β2-adrenergic receptor (β2-ADR) agonist has been shown to attenuate arthritis. In this study, the expression and signaling of β2-ADR in B cells during collagen-induced arthritis (CIA) were investigated to provide an explanation of why only B cells from arthritic mice are able to improve CIA.
View Article and Find Full Text PDFA randomized, controlled trial of a β2-agonist in painful polyneuropathy.
Pain
May 2021
Department of Neurology and Neurology Research Unit, Odense University Hospital and University of Southern Denmark, Odense, Denmark.
Experimental data have suggested that in neuropathic pain, tricyclic antidepressants may work solely through a β2-agonist action. The aim of this study was to test if the β2-agonist terbutaline relieves painful polyneuropathy. The study was a randomized, double-blind, placebo-controlled and active-controlled, 3-way, cross-over trial among patients with painful polyneuropathy.
View Article and Find Full Text PDFSustained release of tulobuterol from graphene oxide laden hydrogel to manage asthma.
J Biomater Sci Polym Ed
March 2021
Respiratory Department, Hunan Children's Hospital, Changsha, Hunan, China.
Bronchial asthma is a chronic disease which is currently treated using various inhalants. However, the medication adherence with the inhalants is poor due to complex procedure to use them along with frequent dosing. In this paper, we have developed tulobuterol loaded Pluronic® F127-reduced graphene oxide transdermal hydrogel to sustain the release of tulobuterol to manage asthma for days.
View Article and Find Full Text PDFDelta opioid receptors are essential to the antiallodynic action of Β-mimetics in a model of neuropathic pain.
Mol Pain
February 2021
Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
The adrenergic system, because of its reported implication in pain mechanisms, may be a potential target for chronic pain treatment. We previously demonstrated that β-adrenoceptors (β-ARs) are essential for neuropathic pain treatment by antidepressant drugs, and we showed that agonists of β-ARs, that is, β-mimetics, had an antiallodynic effect per se following chronic administration. To further explore the downstream mechanism of this action, we studied here the role of the opioid system.
View Article and Find Full Text PDFVolatile anaesthetic for treatment of respiratory failure from status asthmaticus requiring extracorporeal membrane oxygenation.
BMJ Case Rep
January 2020
Anesthesiology, University of Florida College of Medicine, Gainesville, Florida, USA
A 37-year-old male smoker with asthma presented with status asthmaticus refractory to terbutaline, intravenous magnesium, continuous bronchodilators, steroids, heliox and theophylline infusion. He was intubated on hospital day 2 and cannulated for veno-venous extracorporeal membrane oxygenation (V-V ECMO) on hospital day 3 for refractory respiratory acidosis secondary to hypercapnia and hypoxemia despite maximum medical management over 4 days. He was started on inhaled isoflurane with improvement in peak airway pressures and respiratory acidosis, allowing for prompt weaning from V-V ECMO and extubation.
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