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A lectin produced by a Streptomyces species targets mammalian pancreatic acinar cells in mice and humans.
Sci Rep
January 2025
Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, Duarte, USA.
Lectins are produced in almost all life forms, can interact with targets (glycans) in a cross-kingdom manner and have served as valuable tools for studying glycobiology. Previously, a bacterial lectin, named Streptomyces hemagglutinin (SHA), was found to agglutinate human type B erythrocytes. However, the binding of SHA to mammalian cell types other than human erythrocytes has not been explored.
View Article and Find Full Text PDFPre-emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients.
Cochrane Database Syst Rev
January 2025
Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.
Background: Cytomegalovirus (CMV) is a significant cause of morbidity and death in solid organ transplant recipients. Pre-emptive treatment of patients with CMV viraemia using antiviral agents has been suggested as an alternative to routine prophylaxis to prevent CMV disease. This is an update of a Cochrane review first published in 2006 and updated in 2013.
View Article and Find Full Text PDFSignificant association of miRNA 34a with BRCA1 expression in pancreatic ductal adenocarcinoma: an insight on miRNA regulatory pathways in the Pakistani population.
BMC Cancer
December 2024
Department of Surgery, Aga Khan University Hospital, P.O. Box 3500, Stadium Road, Karachi, 74800, Pakistan.
Article Synopsis
- PDAC is a highly aggressive cancer with poor survival rates, and this study examines the role of specific regulatory miRNAs in Pakistani patients with the disease.
- The research involved analyzing tumor samples from 109 PDAC patients to measure the expression of four miRNAs and their interaction with key proteins related to cancer signaling pathways.
- Results showed that miRNA 34a, 30b, and 142 had high expression in about 69-70% of cases, with miRNA 34a significantly associated with BRCA1 expression, while p53 exhibited the lowest expression among the proteins studied.
Evaluating Readability and Reliability of Online Information Provided by Pancreas Transplant Centers in the United States.
Clin Transplant
December 2024
Department of Surgery, Transplantation Center, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Background: The decision of proceeding with a pancreas transplant (PTx) is a complex one, and patient education is important to allow transplant candidates to make an informed and autonomous decision. In this study, we assessed the readability and reliability of online information provided by PTx centers in the United States.
Methods: Websites of PTx centers active between 2022 and 2023 were searched for patient information on pancreas transplantation.
Assessment of vascular invasion of pancreatic ductal adenocarcinoma based on CE-boost black blood CT technique.
Insights Imaging
December 2024
Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
Article Synopsis
- This study investigates the effectiveness of two advanced imaging techniques, AiCE and AIDR 3D, combined with or without the black blood CT (BBCT) approach, for detecting vascular invasion in patients with nonmetastatic pancreatic ductal adenocarcinoma (PDAC).
- A total of 35 patients underwent contrast-enhanced abdominal CT scans, with images analyzed for quality and diagnostic performance by two observers, using metrics like Cohen's kappa and area under the curve (AUC) for evaluation.
- The findings indicate that the combination of AiCE and BBCT significantly improves image quality and diagnostic accuracy for detecting vascular invasion, demonstrating high sensitivity and specificity, which could influence treatment decisions for patients with PDAC.
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