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Objective: Removal of a transcutaneous osseintegrated endo-fix stem (ESKA Orthopaedic, Lübeck, Germany) following a fatigue fracture of the implant, whilst protecting the residual femur bone to allow transcutaneous osseointegrated prosthesis system (TOPS) reimplantation.

Indications: A patient's request for a further TOPS implantation following a fatigue fracture of a circular osseointegrated implant stem.

Contraindications: Impending destruction of the bone tube through mobilisation of the femoral implant stem with insufficient thickness of the cortical wall (< 2-3 mm).

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Sevoflurane (Sev) is a widely applied anesthetic in clinical practice; however, it could induce neurotoxicity and lead to postoperative cognitive dysfunction (POCD). This study aimed to investigate the role and underlying mechanism of circHOMER1 in Sev-induced neurotoxicity and POCD. Sev treated mouse hippocampal neuronal HT22 cells and SD rats.

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Purpose: Restoring ferrule-lacking, noncircular canal endodontically treated teeth (ETT) poses challenges owing to the increased susceptibility to root fracture and post dislodgement. We aimed to evaluate the influence of different post and core materials on the stress distribution and maximum Von Mises stress in ETT.

Methods: Four three-dimensional models were generated using different customized post and core materials: gold alloy, resin nanoceramic, polyetheretherketone (PEEK), and polyetherketoneketone (PEKK).

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Does Improved Resection Plane Coverage During Shoulder Arthroplasty Influence Proximal Humeral Bone Stress? A Comparison of Circular vs. Elliptical Humeral Heads.

J Shoulder Elbow Surg

December 2024

Department of Mechanical Engineering, Western University, London, ON, Canada; The Roth|McFarlane Hand and Upper Limb Centre, St. Joseph's Hospital, London, ON, Canada; Department of Surgery, Western University, London, ON, Canada. Electronic address:

Introduction: Stress shielding remains a concern following total shoulder arthroplasty using press-fit short humeral stems. While the effect of alterations in implant geometry, positioning, and sizing on stress shielding have been investigated, the effects of coverage of the cortical boundary of the resection plane have not yet been fully explored. The purpose of this study was to quantify the effect of improved cortical coverage using elliptical vs.

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Circular RNAs (circRNAs) are novel class of stable regulatory RNAs abundantly expressed in the brain. However, their role in fear extinction (EXT) memory remains largely unexplored. To investigate the mechanisms of Circular Special AT-rich Sequence Binding Protein 2 (circSatb2) in EXT memory, we constructed a lentivirus overexpressing circSatb2 and injected it into the infralimbic prefrontal cortex (ILPFC) of the mouse brain.

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