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Elucidation of the pluripotent potential of bovine embryonic lineages facilitates the establishment of formative stem cell lines.
Cell Mol Life Sci
October 2024
State Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, 100193, People's Republic of China.
Article Synopsis
- Researchers established epiblast-derived pluripotent stem cells (bEpiSCs) from cattle to improve agricultural biotechnology, addressing challenges in embryonic epiblast development and stem cell self-renewal signaling.
- Using modified single-cell transcription sequencing, they monitored gene expression during six key stages of bovine embryonic development and discovered similarities with pigs, which aided in successful bEpiSC generation.
- The resulting bEpiSCs showed stable expression of pluripotency genes, maintained growth for over 112 passages, and demonstrated potential for various applications, including cultured meat production, gene editing, and animal breeding.
Generation, characterization, and differentiation of induced pluripotent stem-like cells in the domestic cat.
J Reprod Dev
December 2023
Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598-8531, Japan.
Induced pluripotent stem (iPS) cells are generated from somatic cells and can differentiate into various cell types. Therefore, these cells are expected to be a powerful tool for modeling diseases and transplantation therapy. Generation of domestic cat iPS cells depending on leukemia inhibitory factor has been reported; however, this strategy may not be optimized.
View Article and Find Full Text PDFBilateral corneal dermoids associated with bilateral choroido-scleral colobomas in a cat: retinographic and optical coherence tomography study with surgical outcome and follow-up.
Vet Ophthalmol
July 2023
Clinique Vétérinaire des Ducs de Bourgogne, Chenove, France.
Purpose: To report a case of feline bilateral corneal dermoids, associated with unilateral iris coloboma and bilateral choroido-scleral colobomas in the same dorsolateral position, to describe retinographic and optical coherence tomography (OCT) characteristics, surgical outcome, and follow-up.
Animal Studied: A 9-month-old domestic shorthaired cat in which a full ophthalmoscopic examination was performed for evaluation of dermoids resulting in a diagnosis of associated iris coloboma in one eye and posterior colobomas in both eyes.
Procedures: Retinographies and OCT were performed under anesthesia to characterize the lesions of both fundi and allow surgical excision of the corneal dermoids.
Reprogramming efficiency and pluripotency of mule iPSCs over its parents†.
Biol Reprod
June 2023
The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010020, China.
The mule is the interspecific hybrid of horse and donkey and has hybrid vigor in muscular endurance, disease resistance, and longevity over its parents. Here, we examined adult fibroblasts of mule (MAFs) compared with the cells from their parents (donkey adult fibroblasts and horse adult fibroblasts) (each species has repeated three independent individuals) in proliferation, apoptosis, and glycolysis and found significant differences. We subsequently derived mule, donkey, and horse doxycycline (Dox)-independent induced pluripotent stem cells (miPSCs, diPSCs, and hiPSCs) from three independent individuals of each species and found that the reprogramming efficiency of MAFs was significantly higher than that of cells of donkey and horse.
View Article and Find Full Text PDFA case of immature teratoma with nephroblastic components in the oral cavity of a cat.
J Vet Med Sci
March 2023
North Lab, Hokkaido, Japan.
A 2-month-old female mixed cat was emaciated due to dysphagia, and inspection of the mouth revealed a 2 cm pedunculated mass elongated from the palate, which occupied the oral cavity. The mass was surgically removed, and histopathological examination revealed that the tumor was composed of three germ cell layers: ectodermal (skin and skin appendages), mesodermal (cartilaginous and osseous structures), and endodermal (glandular and respiratory mucosa) tissues. An immature teratoma was diagnosed because of the presence of immature neuroectodermal tissues, and the presence of nephroblastic components was a characteristic finding in this case.
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