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Fibrinolytic uses in the emergency department: a narrative review.
Am J Emerg Med
December 2024
Department of Emergency Medicine, Rush University Medical Center, Chicago, IL, USA.
Introduction: Several life-threatening conditions associated with thrombosis include acute ischemic stroke (AIS), acute myocardial infarction (AMI), and acute pulmonary embolism (PE). Fibrinolytics are among the treatment algorithms for these conditions.
Objective: This narrative review provides emergency clinicians with an overview of fibrinolytics for AIS, AMI, and PE in the emergency department (ED) setting.
Isolation of methyl caffeate and flacourtin from with comprehensive and pharmacological evaluation.
Heliyon
December 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.
Article Synopsis
- The Indian Coffee Plum (Flacourtia jangomas) is a medicinal plant known for its bioactive compounds and potential therapeutic benefits, prompting research into its extracts from bark for medical applications.
- The study involved extracting phytochemicals using methanol, conducting screenings, and comparing the biological activities of the extracts, revealing the presence of new compounds like methyl caffeate and flacourtin.
- Results showed the extract has strong antioxidant and cytotoxic properties, pain relief effects, and moderate thrombolytic action, but limited antibacterial and antifungal activities, indicating a need for further research on its bioactive compounds.
Deciphering and Pharmacological Properties of Seed and Fruit Extracts of (Lour.) Raeusch.
Adv Pharmacol Pharm Sci
July 2024
School of Pharmacy BRAC University, 41-Pacific Tower, Mohakhali, Dhaka 1212, Bangladesh.
The objective of the study was to evaluate the pharmacological properties of the methanolic extract of (Lour.) Raeusch fruits (PFJM) and seeds (SFJM), along with their soluble fractions in ethyl acetate (fruit: PFJE; seed: SFJE) and chloroform (fruit: PFJC; seed: SFJC). Our phytochemical analysis of the examined extracts confirmed the presence of various therapeutically active phytoconstituents, including flavonoids, tannins, glycosides, and alkaloids.
View Article and Find Full Text PDFEvaluation of clinical efficacy of streptokinase by comparison with the thrombolytic agent on animal model.
Braz J Biol
March 2024
Najran University, Advanced Materials and Nano-Research Centre - AMNRC, Najran, Saudi Arabia.
Cardiovascular disorders, including acute myocardial infarction (AMI), often lead to blood clot formation, impacting blood circulation. Streptokinase, a cost-effective and widely available thrombolytic agent, is crucial in treating thrombosis. This study aimed to produce streptokinase from Streptococcus pyogenes EBL-48 and compare its efficacy with heparin in an animal model.
View Article and Find Full Text PDFChemical Adjustment of Fibrinolysis.
Pharmaceuticals (Basel)
January 2024
Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 109029 Moscow, Russia.
Fibrinolysis is the process of the fibrin-platelet clot dissolution initiated after bleeding has been stopped. It is regulated by a cascade of proteolytic enzymes with plasmin at its core. In pathological cases, the balance of normal clot formation and dissolution is replaced by a too rapid lysis, leading to bleeding, or an insufficient one, leading to an increased thrombotic risk.
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