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Maternal and Fetal Complications in Pregnant Women with Neurofibromatosis Type 1: Literature Review and Two Case Reports.
J Clin Med
January 2025
"Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Neurofibromatosis is a genetic disorder arising de novo or with an autosomal dominant transmission that typically presents either at birth or in early childhood, manifesting through distinctive clinical features such as multiple café-au-lait spots, benign tumors in the skin, bone enlargement, and deformities. This literature review aims to resume the spectrum of maternal and fetal complications encountered in pregnant women with neurofibromatosis type 1 (NF1). Thorough research was conducted on databases such as Web of Science, PubMed, Science Direct, Google Scholar, and Wiley Online Library.
View Article and Find Full Text PDFImpact of sex hormones on pheochromocytomas, paragangliomas, and gastroenteropancreatic neuroendocrine tumors.
Eur J Endocrinol
January 2025
Department of Internal Medicine IV, LMU University Hospital, LMU Munich, 80336 Munich, Germany.
Objective: The effects of sex hormones remain largely unexplored in pheochromocytomas and paragangliomas (PPGLs) and gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
Methods: We evaluated the effects of estradiol, progesterone, Dehydroepiandrosterone sulfate (DHEAS), and testosterone on human patient-derived PPGL/GEP-NET primary culture cell viability (n = 38/n = 12), performed next-generation sequencing and immunohistochemical hormone receptor analysis in patient-derived PPGL tumor tissues (n = 36).
Results: In PPGLs, estradiol and progesterone (1 µm) demonstrated overall significant antitumor effects with the strongest efficacy in PPGLs with NF1 (cluster 2) pathogenic variants.
Safety of electroconvulsive therapy in the context of physiological and medical complexity: A state-of-the art review.
PCN Rep
March 2025
Division of Mental Health and Wellbeing Western Health Melbourne Victoria Australia.
Medical contraindications and complications pose challenges for electroconvulsive therapy (ECT). Most published reports are scattered across various physiological systems and individual disease conditions. This review aimed to evaluate the literature on physiological and medical complexities during ECT and discuss risk mitigation strategies in a comprehensive review.
View Article and Find Full Text PDFUnmasking the Hidden Threat: A Case Report of the Anesthetic Management of a Catecholamine-Secreting Tumor in Pregnancy.
Cureus
October 2024
Anesthesiology, Unidade Local de Saúde do Alto Ave, Guimarães, PRT.
Article Synopsis
- - Catecholamine-secreting tumors (CSTs) are rare but can pose serious risks for both mother and baby during pregnancy, often complicating diagnosis due to similarities with conditions like preeclampsia.
- - A case study of a 24-year-old pregnant woman revealed that timely management of hypertension and surgical intervention were crucial; she was diagnosed with a CST at 27 weeks, managed with medication, and had an elective cesarean at 32 weeks, delivering a healthy baby.
- - Successful outcomes depend on early diagnosis, tailored medical and surgical approaches, and teamwork among various healthcare specialists, emphasizing the need for heightened awareness of CSTs in hypertensive pregnant patients.
[Paraganglioma and pregnancy: A thrilling urination story].
Gynecol Obstet Fertil Senol
January 2025
Gynécologie-obstétrique et médecine de la reproduction, CHU de Caen, avenue de la Côte de Nacre, 14000 Caen, France; UFR médecine Caen, rue des Rochambelles, 14000 Caen, France.
Objectives: Carrying out a pregnancy to term in a patient with a paraganglioma or pheochromocytoma (PPGL) results from a multidisciplinary challenge. The objective was to compare our therapeutic attitude with the existing literature and to identify optimal treatment.
Methods: Description of a case of paraganglioma treated during pregnancy at the University Hospital Center of Caen (France) in 2024 and comparison with the literature.
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