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Evaluation of coagulation by thromboelastography and a velocity curve in dogs with parvoviral enteritis.
Vet Med (Praha)
October 2024
Department of Internal Medicine, Faculty of Veterinary Medicine, Bursa Uludag University, Bursa, Turkey.
Article Synopsis
- The study investigates the coagulation status of dogs with canine parvoviral enteritis (CPE), a severe condition that can lead to high mortality due to systemic inflammation and multi-organ dysfunction.
- It involved 21 dogs diagnosed with CPE and 5 healthy controls, using thromboelastography (TEG) to analyze coagulation, showing significant differences in reaction times and clot dissolution rates.
- The findings suggest that TEG-derived velocity curve (v-curve) parameters could be a better method to assess coagulation in CPE cases, offering new insights for diagnosis and treatment strategies.
Objective: To use a point-of-care viscoelastic coagulation monitoring device (VCM-Vet; Entegrion) and traditional tests to assess hemostatic changes during hemorrhagic shock in dogs.
Methods: 8 healthy, purpose-bred Beagles were enrolled in a hemorrhagic shock model conducted from September through December 2021. Dogs were anesthetized, had baseline hemostatic variables measured after blood pressure was stabilized at 70 to 80 mm Hg for 10 minutes (T1), had blood withdrawn from a jugular vein to achieve a mean blood pressure of 40 ± 5 mm Hg for 10 minutes (T2), were resuscitated with 100% shed blood, and then had hemostatic variables evaluated 10 minutes later (T3).
Thromboelastography in dogs with idiopathic epilepsy treated with phenobarbital monotherapy.
Vet Clin Pathol
September 2024
Servei de Neurologia, Fundació Hospital Clínic Veterinari, Campus Universitat Autònoma de Barcelona, Bellaterra, Spain.
Background: Thromboelastography (TEG) is an effective technique to assess the efficiency of coagulation. Phenobarbital (PB) can induce hematological and coagulation disorders in both animals and humans, but its effects on hemostasis have been little investigated and are poorly understood in dogs.
Objectives: The aim of this article was to assess coagulation using TEG in a population of dogs with idiopathic epilepsy treated with PB.
Tranexamic acid stops hyperfibrinolysis in dogs with hemorrhagic shock: a randomized, controlled clinical trial.
J Am Vet Med Assoc
January 2025
3Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
Objective: To determine the effect of tranexamic acid (TXA) on clot hyperfibrinolysis (HF), defined as excessive clot lysis at 30 minutes (LY30%), with rapid thromboelastography (rTEG) or rTEG samples spiked with tissue plasminogen activator (tPA-stressed rTEG), in dogs with hemorrhagic shock.
Methods: Prospective blinded clinical trial at 2 teaching hospitals, March 16, 2018, to May 20, 2022. Twenty-five dogs with hemorrhagic shock and HF were treated with standard care plus either TXA (20 mg/kg; TXA group) or saline (SAL group) over 20 minutes followed by an infusion of the same dose over 8 hours.
The effect of prophylactic tranexamic acid on the incidence of postoperative hemorrhage in greyhounds.
Vet J
December 2024
Small Animal Hospital, Langford Veterinary Services, Langford, Somerset BS40 5DU, United Kingdom.
To investigate whether the incidence of postoperative hemorrhage in greyhounds was reduced when a standardized protocol for prophylactic tranexamic acid (TXA) administration to greyhounds undergoing surgery was followed, a retrospective clinical study at a private referral and first opinion hospital group was performed. Patient records of client-owned greyhounds undergoing elective surgery or dental procedures involving extractions were examined retrospectively, and 58 incidents of surgery considered eligible were documented, along with any subsequent reports of hemorrhage and whether the TXA protocol was followed. The use of TXA was not associated with a reduction in the incidence of postoperative hemorrhage in this population of greyhounds.
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