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Pediatric Formulation Optimization Using a Rational Design: Exploring Amorphous Solid Dispersion Technology with Terbinafine Hydrochloride as a Case Study.
AAPS PharmSciTech
January 2025
Department of Chemistry, Center for Physical and Mathematical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
Developing orally administered pediatric formulations presents significant challenges due to the unique characteristics of pediatric patients. Terbinafine hydrochloride (TER), a powerful antifungal agent, is effective against various fungal infections, including Tinea capitis, which is common in children. However, its low aqueous solubility necessitates innovative pharmaceutical strategies to enhance its effectiveness.
View Article and Find Full Text PDFA New and Safe Delivery of Sildenafil Citrate Co-Evaporate Loaded Emulgels for the Cure of Certain Male Sexual Dysfunctions.
AAPS PharmSciTech
January 2025
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.
The present work focuses on the production of sildenafil co-evaporates loaded emulgels as topical dosage forms for the treatment of premature ejaculation and erectile dysfunction. Topical administration of sildenafil citrate (SILD) co-evaporates is expected to improve the bioavailability profile of the drug and to avoid the severe side effects accompanying the traditional SILD dosage forms, especially for prohibited cardiovascular cases. Firstly, the solubility of SILD was improved via solid dispersion via co-evaporation technique using PEG-5KDa and PVP-K90 as hydrophilic carriers.
View Article and Find Full Text PDFA Novel Facile and Efficient Prophylaxis Avenue of Chitosan Oligosaccharide/PLGA Based Polydatin Loaded Nanoparticles Against Bleomycin-Induced Lung Inflammation in Experimental Rat Model.
AAPS PharmSciTech
January 2025
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Dakahlia, Egypt.
Lung inflammation is a hallmark of several respiratory diseases. Despite the great effectiveness of the synthetic antiinflammatory agents, they cause potential side effects. Polydatin (PD), a natural phytomedicine, has antioxidant and antiinflammatory effects.
View Article and Find Full Text PDFImpact of nanostructured formulations for schistosomiasis treatment: a systematic review of in vivo preclinical evidence.
J Pharm Pharmacol
January 2025
Departamento de Parasitologia e Patologia, Universidade Federal de Alfenas, Alfenas, 37130-001, Minas Gerais, Brazil.
Background: Schistosomiasis is a neglected tropical disease caused by Schistosoma sp., and praziquantel (PZQ) is the first-line treatment. However, traditional PZQ formulations have low solubility and fast metabolism, limiting its effectiveness.
View Article and Find Full Text PDFEnhancing Microemulsion-Based Therapeutic Drug Delivery: Exploring Surfactants, Co-Surfactants, and Quality-by-Design Strategies within Pseudoternary Phase Diagrams.
Crit Rev Ther Drug Carrier Syst
January 2025
Associate Professor of Pharmaceutics, Faculty of Health and Allied Sciences, Amity University Noida India, Pharmaceutics Domain, Uttar Pradesh, India; Member, Indian National Young Academy of Sciences (INYAS), INSA, New Delhi, India.
Microemulsions (MEs) are homogeneous, isotropic, transparent, and thermodynamically stable mixtures of water, oil, and surfactants. Their unique properties have garnered increasing interest across various fields, including chemistry, pharmacology, biotechnology, and biology. This review aims to provide a comprehensive overview of ME compositions, their macroscopic appearances, and the roles of their essential components - oil, water, surfactant, and co-surfactant - in controlling the nature and stability of MEs.
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