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Editorial for the Special Issue 'Molecular Breeding and Genetics Research in Plants'.
Curr Issues Mol Biol
December 2024
Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon 24341, Republic of Korea.
Despite significant advancements in plant breeding research, the challenges posed by a growing global population, the impact of abiotic and biotic stresses, and the uncertainties of climate change necessitate continued focus and innovation in plant breeding and genetic studies [...
View Article and Find Full Text PDFESAT-6 protein suppresses allograft rejection by inducing CD4Foxp3 regulatory T cells through IκBα/cRel pathway.
Front Immunol
January 2025
Section of Immunology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Background: Maintenance immunosuppression is required for suppression of alloimmunity or allograft rejection. However, continuous use of immunosuppressants may lead to various side effects, necessitating the use of alternative immunosuppressive drugs. The early secreted antigenic target of 6 kDa (ESAT-6) is a virulence factor and immunoregulatory protein of mycobacterium tuberculosis (Mtb), which alters host immunity through dually regulating development or activation of various immune cells.
View Article and Find Full Text PDFAnatomical, functional, and blood-born predictors of severity of brachycephalic obstructive airway syndrome severity in French Bulldogs.
Front Vet Sci
January 2025
Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Brachycephalic breeds suffer from respiratory distress known as brachycephalic obstructive airway syndrome (BOAS) and the multiple comorbidities associated with it. Targeted breeding toward a more BOAS-free phenotype requires accurate and least invasive detection of BOAS severity grades that are accessible and accepted by the breeders and kennel clubs. This study aimed to compare the-outcome of morphometric anatomical examination with functional tests such as exercise tests and plethysmography for the detection of BOAS severity in a group of 84 French Bulldogs.
View Article and Find Full Text PDFApplication and development of CRISPR technology in the secondary metabolic pathway of the active ingredients of phytopharmaceuticals.
Front Plant Sci
January 2025
College of Life Sciences, Northwest Agricultural and Forestry University, Yangling, Shaanxi, China.
As an efficient gene editing tool, the CRISPR/Cas9 system has been widely employed to investigate and regulate the biosynthetic pathways of active ingredients in medicinal plants. CRISPR technology holds significant potential for enhancing both the yield and quality of active ingredients in medicinal plants. By precisely regulating the expression of key enzymes and transcription factors, CRISPR technology not only deepens our understanding of secondary metabolic pathways in medicinal plants but also opens new avenues for drug development and the modernization of traditional Chinese medicine.
View Article and Find Full Text PDFPeptide hormones in plants.
Mol Hortic
January 2025
Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
Peptide hormones are defined as small secreted polypeptide-based intercellular communication signal molecules. Such peptide hormones are encoded by nuclear genes, and often go through proteolytic processing of preproproteins and post-translational modifications. Most peptide hormones are secreted out of the cell to interact with membrane-associated receptors in neighboring cells, and subsequently activate signal transductions, leading to changes in gene expression and cellular responses.
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