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Phenotypic traits and family history in patients with 22q11.2 deletion syndrome and generalized epilepsy: A multicenter case-control study.
Epilepsia
December 2024
Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Objective: This study was undertaken to characterize the clinical and genetic features of patients with 22q11.2 deletion syndrome (22q11.2DS) and generalized epilepsy compared with 22q11.
View Article and Find Full Text PDFEffect of in utero exposure to antiepileptic drugs on cortical networks and neurophysiological outcomes at 6 years.
Epilepsia
November 2024
BABA Center, Pediatric Research Center, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland.
Article Synopsis
- The study explores how antiepileptic drugs (AEDs) taken by pregnant mothers affect brain activity in children, particularly focusing on those exposed to AEDs in utero compared to those who weren't.
- Researchers analyzed EEG recordings from 6-year-old children to examine differences in cortical activity networks during sleep and their connection to cognitive performance.
- Results indicate that children exposed to AEDs show significant long-lasting changes in brain activity networks, which correlate with neurocognitive performance, suggesting potential risks associated with AED use during pregnancy.
Comprehensive assessment of memory function, inhibitory control, neural activity, and cortisol levels in late pregnancy.
Ann N Y Acad Sci
May 2024
Department of Behavioral Sciences, The Center for Psychobiological Research, The Max Stern Yezreel Valley College, Emek Yezreel, Israel.
A considerable proportion of women subjectively perceive a detriment to their cognitive capacity during pregnancy, with decreased memory functions being the most frequently self-reported concerns. However, objective investigation of these perceived cognitive deficits has yielded inconsistent results. This study focused on memory functions during late pregnancy using multiple tasks designed to assess various memory indices, for example, working memory, learning rate, immediate recall, proactive and retroactive interference, delayed recall, retrieval efficiency, visuospatial constructional ability, recognition, and executive function.
View Article and Find Full Text PDFDysmaturation of sleep state and electroencephalographic activity after hypoxia-ischaemia in preterm fetal sheep.
J Cereb Blood Flow Metab
August 2024
The Fetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.
Article Synopsis
- Antenatal hypoxia-ischaemia (HI) in preterm fetal sheep can lead to severe white matter injury (WMI), paralleling conditions observed in preterm infants.
- The study involved preterm fetal sheep, which experienced a 25-minute umbilical cord occlusion or a sham procedure, followed by a 21-day recovery period to assess changes in electroencephalographic (EEG) activity.
- Results indicated that following HI, there was a significant shift to lower frequency EEG activity, a decrease in sleep state cycling, and an abnormal transition to a high-frequency state, which may signal evolving WMI.
Frequency of epilepsy and pathological EEG findings in a Norwegian sample of children with fetal alcohol spectrum disorder: Impact on cognition and adaptive functioning.
Alcohol Clin Exp Res (Hoboken)
February 2024
Regional Competence Center for Children with Prenatal Alcohol/Drug Exposure, Department of Pediatrics, Sørlandet Hospital, Arendal, Norway.
Background: Fetal alcohol spectrum disorder (FASD) comprises a combination of developmental, cognitive, and behavioral disabilities that occur in children exposed to alcohol prenatally. A higher prevalence of epilepsy and pathological electroencephalographic (EEG) features have also been reported in individuals with FASD. We examined the frequency of epilepsy, pathological EEG findings, and their implications for cognitive and adaptive functioning in children with FASD.
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